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Serum CA 125 Levels in Children with Acute Leukemia and Lymphoma

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dc.authorscopusid6507222394
dc.authorscopusid6701582030
dc.authorscopusid7007038407
dc.authorscopusid7005240097
dc.authorscopusid8718211300
dc.authorscopusid6602784315
dc.authorscopusid16744367100
dc.contributor.authorBirgen, D.
dc.contributor.authorErtem, U.
dc.contributor.authorDuru, F.
dc.contributor.authorŞahin, G.
dc.contributor.authorYüksek, N.
dc.contributor.authorBozkurt, C.
dc.contributor.authorKaracan, C.D.
dc.date.accessioned2020-06-21T15:31:04Z
dc.date.available2020-06-21T15:31:04Z
dc.date.issued2005
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Birgen] Dilek, Department of Oncology, Dr. Sami Ulus Children's Hospital, Ankara, Turkey; [Ertem] Ulya, Department of Oncology, Dr. Sami Ulus Children's Hospital, Ankara, Turkey,; [Duru] Feride, Department of Pediatric Hematology, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Şahin] Gürses, Department of Oncology, Dr. Sami Ulus Children's Hospital, Ankara, Turkey; [Yüksek] Nazmiye, Department of Oncology, Dr. Sami Ulus Children's Hospital, Ankara, Turkey; [Bozkurt] Ceyhun, Department of Oncology, Dr. Sami Ulus Children's Hospital, Ankara, Turkey; [Karacan] Can Demir, Department of Oncology, Dr. Sami Ulus Children's Hospital, Ankara, Turkey; [Aksoy] Çǧdem, Department of Endocrinology, Ankara Üniversitesi, Ankara, Turkeyen_US
dc.description.abstractCa 125 is a tumor marker for the diagnosis and monitoring of ovarian carcinoma. We investigated serum Ca 125 levels in 44 children with leukemia and 59 children with lymphoma at initial presentation and 4 weeks after chemotherapy. Serum Ca 125 levels were measured chemilumimetrically with a sandwich enzyme-linked immunosorbent assay. The incidence of elevated serum Ca 125 levels was significantly higher in children with leukemia (14 children) and lymphoma (26 children) than in the healthy children (2 children). In the patients with non-Hodgkin's lymphoma (NHL) who had abdominal involvement and/or serous membrane involvement (ascides, pleural, pericardial effusion) at presentation, serum Ca 125 levels were significantly higher than in the patients without abdominal and/or serosal involvement. Serum Ca 125 levels were impressively increased in the patients with Burkitt's lymphoma (BL) in whom abdominal and/or serous membrane involvement were observed more frequently than the other types of lymphoma. The increased serum Ca 125 levels in the patients returned to normal 4 weeks after chemotherapy when they achieved complete remission. In conclusion, serum Ca 125 seems to be a good indicator for serous membrane involvement and it seems to be a promising tumor marker in the assessment of therapeutic response in children with leukemia and NHL. © 2005 Taylor & Francis Group Ltd.en_US
dc.identifier.doi10.1080/10428190500096690
dc.identifier.endpage1181en_US
dc.identifier.issn1042-8194
dc.identifier.issn1029-2403
dc.identifier.issue8en_US
dc.identifier.pmid16085559
dc.identifier.scopus2-s2.0-23144439413
dc.identifier.scopusqualityQ3
dc.identifier.startpage1177en_US
dc.identifier.urihttps://doi.org/10.1080/10428190500096690
dc.identifier.urihttps://hdl.handle.net/20.500.12712/21000
dc.identifier.volume46en_US
dc.identifier.wosWOS:000231134100010
dc.identifier.wosqualityQ3
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofLeukemia & Lymphomaen_US
dc.relation.journalLeukemia & Lymphomaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCA 125en_US
dc.subjectChildhooden_US
dc.subjectLeukemiaen_US
dc.subjectLymphomaen_US
dc.titleSerum CA 125 Levels in Children with Acute Leukemia and Lymphomaen_US
dc.typeArticleen_US
dspace.entity.typePublication

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