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In Vitro Antifungal, Anticancer Activities and POM Analyses of a Novel Bioactive Schiff Base 4-{[(E)-furan-2-ylmethylidene]amino}p-Henol: Synthesis, Characterization and Crystal Structure

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dc.authorscopusid57160159900
dc.authorscopusid6701440754
dc.authorscopusid55194764100
dc.authorscopusid14832237900
dc.authorscopusid8398877200
dc.authorscopusid56430353500
dc.authorscopusid24376897000
dc.contributor.authorTighadouni, S.
dc.contributor.authorRadi, S.
dc.contributor.authorSirajuddin, M.
dc.contributor.authorAkkurt, M.
dc.contributor.authorÖzdemir, Nutullah
dc.contributor.authorAhmad, M.
dc.contributor.authorMabkhot, Y.N.
dc.date.accessioned2020-06-21T13:39:18Z
dc.date.available2020-06-21T13:39:18Z
dc.date.issued2016
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Tighadouni] Said, Department of Chemistry, Université Mohammed Premier Oujda, Oujda, Oriental, Morocco; [Radi] Smaail, Department of Chemistry, Université Mohammed Premier Oujda, Oujda, Oriental, Morocco; [Sirajuddin] Muhammad, Department of Chemistry, University of Science and Technology, Rawalpindi, Pakistan; [Akkurt] Mehmet, Department of Physics, Erciyes Üniversitesi, Kayseri, Kayseri, Turkey; [Özdemir] Namık, Department of Physics, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Ahmad] Mushtaq,; [Mabkhot] Yahia Nasser, Department of Chemistry, College of Sciences, Riyadh, Riyad, Saudi Arabia; [Ben hadda] T., Laboratoire Chimie Matériaux, Université Mohammed Premier Oujda, Oujda, Oriental, Moroccoen_US
dc.description.abstractThe title compound (1), C<inf>11</inf>H<inf>9</inf>NO<inf>2</inf>, was synthesized and characterized by FT-IR, 1H NMR, 13C NMR spectroscopy, mass spectrometry and single crystal analysis. It was crystallized in a monoclinic system with a space group P2<inf>1</inf>/n. The dihedral angle between the planes of furan and benzene ring is 21.24 (11)°. The torsion angle of bridge -C-C-N-C-is -177.81(15)°. The crystal structue is stabilized by intermolecular hydrogen bonds between O-H...N and C-H...O forming a three dimensional network. The synthesized compound was screened for the in vitro antifungal against the Fusarium oxysporum f.sp albedinis FAO fungal strains and showed good activity. It was also tested for the anticancer activities against breast (MDA-MB231) and colorectal (LOVO) cancer cell lines and exhibited IC<inf>50</inf> values of 6.9 μg/mL and 14.6 μg/mL, respectively. POM calculations of molecular properties of 1 are in good agreement with the mode of antifungal action of the compound bearing (Xδ--Yδ-) pharmacophore site. Also it shows a drug score of 43% which is an important parameter for the compound possessing the drug character.en_US
dc.identifier.endpage165en_US
dc.identifier.issn0253-5106
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84960122107
dc.identifier.scopusqualityQ3
dc.identifier.startpage157en_US
dc.identifier.volume38en_US
dc.identifier.wosWOS:000377764300022
dc.identifier.wosqualityQ4
dc.language.isoenen_US
dc.publisherChemical Society of Pakistan Islamabad H-9en_US
dc.relation.ispartofJournal of the Chemical Society of Pakistanen_US
dc.relation.journalJournal of the Chemical Society of Pakistanen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnticancer Activityen_US
dc.subjectAntifungal Activityen_US
dc.subjectCrystal Structureen_US
dc.subjectNMRen_US
dc.subjectPOM Analysisen_US
dc.titleIn Vitro Antifungal, Anticancer Activities and POM Analyses of a Novel Bioactive Schiff Base 4-{[(E)-furan-2-ylmethylidene]amino}p-Henol: Synthesis, Characterization and Crystal Structureen_US
dc.typeArticleen_US
dspace.entity.typePublication

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