Assessment of Retinal and Choroidal Thicknesses With Using Swept-Source OCT Technology After Intravenous Sodium Fluorescein Application in Patients With Non-Proliferative DRP and Non-Neovascular AMD

Abstract

Purpose: To compare the central macular thickness (CMT), retinal nerve fiber layer thickness (RNFLT), ganglion cell layer thickness (GCLT), and choroidal thickness (CT) measurements in patients with diabetic retinopathy (DRP) and age-related macular degeneration (AMD) before and after intravenous sodium fluorescein application. Methods: The study was conducted cross-sectionally on patients with non-prolipherative DRP and non-neovascular AMD who received intravenous sodium fluorescein for fluorescein angiography (FA). The CMT, RNFLT (in four quadrants), GCLT (in six sectors of two different boundaries), and CT (in five locations) measurements were obtained by swept-source optical coherence tomography (SS- OCT) at baseline, two days after, and one month after FA imaging. Results: The mean age of the patients with DRP (20 women, 18 men) was 64.42 ± 8.98 years (49-87), and that of patients with AMD (20 women, 18 men) was 71.95 ± 10.38 years (48-97). Regarding SS-OCT measurements, all mean CMT, RNFLT (in four quadrants), CT (in five locations), and GCLT values (except temporal-superior quadrant of GCLT+ (p=0.007) and superior quadrant of GCLT++ (p=0.06) in patients with DRP) were similar in baseline, two days, and one month after imaging (p>0.05 for all). Conclusion: The current study has shown that sodium fluorescein may be affect the measurements of ganglion cell layer thicknesses. This effect may be reversible, however due to the better understood of this issue, large-participated study groups are needed.