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Chromone Containing Sulfonamides as Potent Carbonic Anhydrase Inhibitors

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dc.authorscopusid23027537500
dc.authorscopusid36674451900
dc.authorscopusid36242824300
dc.authorscopusid23013520200
dc.authorscopusid7102904152
dc.contributor.authorEkinci, D.
dc.contributor.authoral-Rashida, M.
dc.contributor.authorAbbas, G.
dc.contributor.authorŞentürk, M.
dc.contributor.authorSupuran, C.T.
dc.date.accessioned2020-06-21T14:17:44Z
dc.date.available2020-06-21T14:17:44Z
dc.date.issued2012
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Ekinci] Deniz, Department of Agricultural Biotechnology, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [al-Rashida] Mariya, Institute of Chemistry, University of the Punjab, Lahore, Punjab, Pakistan; [Abbas] Ghulam, Institute of Chemistry, University of the Punjab, Lahore, Punjab, Pakistan; [Şentürk] Murat, Department of Chemistry, Aǧrı İbrahim Çeçen Üniversitesi, Agri, Agri, Turkey; [Supuran] Claudiu T., Laboratorio di Chimica Bioinorganica, Università degli Studi di Firenze, Florence, FI, Italyen_US
dc.description.abstractA series of sulfonamide derivatives incorporating substituted 3-formylchromone moieties were investigated for the inhibition of three human carbonic anhydrase (hCA, EC 4.2.1.1) isoforms, hCA I, II, and VI. All these compounds, together with the clinically used sulfonamide acetazolamide, were investigated as inhibitors of the physiologically relevant isozymes I, II (cytosolic), and VI (secreted isoform). These sulfonamides showed effective inhibition against all these isoforms with KI's in the range of 0.228 to 118 M. Such molecules can be used as leads for discovery of novel effective CA inhibitors against other isoforms with medicinal chemistry applications. © 2012 Informa UK, Ltd.en_US
dc.identifier.doi10.3109/14756366.2011.614607
dc.identifier.endpage747en_US
dc.identifier.issn1475-6366
dc.identifier.issn1475-6374
dc.identifier.issue5en_US
dc.identifier.pmid21985426
dc.identifier.scopus2-s2.0-84866092055
dc.identifier.scopusqualityQ1
dc.identifier.startpage744en_US
dc.identifier.urihttps://doi.org/10.3109/14756366.2011.614607
dc.identifier.volume27en_US
dc.identifier.wosWOS:000308533100016
dc.identifier.wosqualityQ1
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Enzyme Inhibition and Medicinal Chemistryen_US
dc.relation.journalJournal of Enzyme Inhibition and Medicinal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEnzyme Inhibitorsen_US
dc.subjectHuman Carbonic Anhydraseen_US
dc.subjectSchiff's Baseen_US
dc.subjectSulfonamidesen_US
dc.titleChromone Containing Sulfonamides as Potent Carbonic Anhydrase Inhibitorsen_US
dc.typeArticleen_US
dspace.entity.typePublication

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