Effectiveness of Nalidixic Acid and Commonly Used Antibiotics Against Pathogens of Urinary System

Abstract

Aim: Medicines for treatment Urinary tractinfections in common population are ineffective due to long usage and developing resistance. Nowadays quinolones are first choise for empiric treatment this infections. Nalidixic acid is first used quinolone type antimicrobial in this group. Because of developing resistance and side effects new quinolo nes have found treatment instead of nalidixic acid. For urinary system infections. In our study we aimed to compare resistance to nalidixic acid, fosfomycin and other frequently used oral antimicrobials. Material and Method: We studied 314 urine specimens from Medical Faculty Hospital's various clinic in microbiology laboratory. After 24 hours incubation the bacteria's media that cultured were examined. Bacteria were identified with conventional and automatic systems (Vitec 2 Compact bioMerieux, France). Antibiotic suseptibility tested were made with CirbyBauer method and evaluateda according to Clinical Laboratory Standards Institute standards. Results: 241 (79,8%) E.coli, 53 (16,9%) Klebsiella spp. 11 (3,5%) Proteus spp. and 9 Enterobacter spp. bacteria were identified from urine samples.. All strains resistant rate belong to Enterobacteriaceae to nalidixic acid. trimethoprim-sulfamethoxazole, cefuroxime, ciprofloxacin, norfloxacin, nitrofurantoin and fosfomycin were given 42.3% 4L4 To, 32.8 %, 28.6%, 31.5 cIY,14.6% 8.5 in respectively. Mostly isolated bacterial from urine was E.coli with high potency to fosfomycin with 2.9% resistance rate was followed by nitrofurantion (resistance rate 6,9%), Cefuroxime, ciprofloxacin, norfloxacin, trimethoprim-sulfamethoxazole, nalidixic acid resistance rate were 6.2%, 30.2%, cIb32.3, %35.3, %46.4, %46.8 in order. Discussion: As result resistance to nalidixic acide not decreased despite not being in use for a long time and were determined that fosfomycin more susceptible fortreatwent urinary tract infections.