Publication:
Smoking-Induced Genetic and Epigenetic Alterations in Infertile Men

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dc.authorscopusid6603432100
dc.authorscopusid57192679453
dc.authorscopusid57104572000
dc.authorscopusid16194084100
dc.contributor.authorGüneş, S.
dc.contributor.authorMetin Mahmutoglu, A.
dc.contributor.authorArslan, M.A.
dc.contributor.authorHenkel, R.
dc.date.accessioned2020-06-21T13:06:09Z
dc.date.available2020-06-21T13:06:09Z
dc.date.issued2018
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Güneş] Sezgin Özgür, Department of Medical Biology, Ondokuz Mayis Üniversitesi, Samsun, Turkey, Department of Multidisciplinary Molecular Medicine, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Metin Mahmutoglu] Asli, Department of Medical Biology, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Arslan] Mehmet Alper, Department of Medical Biology, Ondokuz Mayis Üniversitesi, Samsun, Turkey, Department of Multidisciplinary Molecular Medicine, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Henkel] Ralf Reinhold, Department of Medical Biosciences, University of the Western Cape, Bellville, Western Cape, South Africaen_US
dc.description.abstractMale fertility rates have shown a progressive decrease in both developing and industrialised countries in the past 50 years. Clinical and epidemiological studies have demonstrated controversial results about the harmful effects of cigarette smoking on seminal parameters. Some studies could not establish a negative effect by tobacco smoking on sperm quality and function, whereas others have found a significant reduction in sperm quality and function. This study reviews the components in cigarette smoke and discusses the effects of smoking on male fertility by focusing extensively on smoking-induced genetic and epigenetic alterations in infertile men. Chromosomal aneuploidies, sperm DNA fragmentation and gene mutations are discussed in the first section, while changes in DNA methylation, chromatin remodelling and noncoding RNAs are discussed in the second section as part of epigenetic alterations. © 2018 Blackwell Verlag GmbHen_US
dc.identifier.doi10.1111/and.13124
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue9en_US
dc.identifier.pmid30132931
dc.identifier.scopus2-s2.0-85053203386
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1111/and.13124
dc.identifier.urihttps://hdl.handle.net/20.500.12712/11323
dc.identifier.volume50en_US
dc.identifier.wosWOS:000446978500019
dc.identifier.wosqualityQ3
dc.language.isoenen_US
dc.publisherBlackwell Publishing Ltden_US
dc.relation.ispartofAndrologiaen_US
dc.relation.journalAndrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCigarette Smokeen_US
dc.subjectDNA Fragmentationen_US
dc.subjectEpigeneticsen_US
dc.subjectGenetic Alterationsen_US
dc.subjectOxidative Stressen_US
dc.titleSmoking-Induced Genetic and Epigenetic Alterations in Infertile Menen_US
dc.typeArticleen_US
dspace.entity.typePublication

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