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Synthesis of Novel Substituted Purine Derivatives and Identification of the Cell Death Mechanism

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dc.authorscopusid56811155700
dc.authorscopusid56406217900
dc.authorscopusid7004145119
dc.authorscopusid8600292400
dc.authorscopusid6602870986
dc.authorscopusid6701749348
dc.contributor.authorDemir, Z.
dc.contributor.authorGuven, E.B.
dc.contributor.authorÖzbey, S.
dc.contributor.authorKazak, C.
dc.contributor.authorCetin-Atalay, R.C.
dc.contributor.authorTunçbílek, M.
dc.date.accessioned2020-06-21T13:51:03Z
dc.date.available2020-06-21T13:51:03Z
dc.date.issued2015
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Demir] Zeynep, Department of Pharmaceutical Chemistry, Ankara Üniversitesi, Ankara, Turkey; [Guven] Ebru Bilget, Bilkent Üniversitesi, Ankara, Ankara, Turkey; [Özbey] Süheyla, Department of Engineering Physics, Hacettepe Üniversitesi, Ankara, Turkey; [Kazak] Canan, Department of Physics, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Cetin-Atalay] Rengul, Bilkent Üniversitesi, Ankara, Ankara, Turkey; [Tunçbílek] Meral, Department of Pharmaceutical Chemistry, Ankara Üniversitesi, Ankara, Turkeyen_US
dc.description.abstractNovel substituted adenine and purine derivatives were designed and synthesized.Compound 36 displayed the greatest cytotoxic activity with IC<inf>50</inf> less than 1 1/4M.36 induces senescence associated cell death, which was demonstrated with SA2-Gal assay. © 2014 Elsevier Masson SAS.en_US
dc.identifier.doi10.1016/j.ejmech.2014.10.080
dc.identifier.endpage720en_US
dc.identifier.issn0223-5234
dc.identifier.issn1768-3254
dc.identifier.pmid25462277
dc.identifier.scopus2-s2.0-84908688997
dc.identifier.scopusqualityQ1
dc.identifier.startpage701en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejmech.2014.10.080
dc.identifier.volume89en_US
dc.identifier.wosWOS:000348003500058
dc.identifier.wosqualityQ1
dc.language.isoenen_US
dc.publisherElsevier Masson SAS infos@masson.fr 62 rue Camille Desmoulins Issy les Moulineaux Cedex 92442en_US
dc.relation.ispartofEuropean Journal of Medicinal Chemistryen_US
dc.relation.journalEuropean Journal of Medicinal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdenineen_US
dc.subjectCytotoxic Activityen_US
dc.subjectHepatocellular Carcinomaen_US
dc.subjectPurine Derivativesen_US
dc.subjectSenescenceen_US
dc.titleSynthesis of Novel Substituted Purine Derivatives and Identification of the Cell Death Mechanismen_US
dc.typeArticleen_US
dspace.entity.typePublication

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