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Synthesis and Carbonic Anhydrase Inhibitory Properties of Novel Bromophenols Including Natural Products

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dc.authorscopusid54882270000
dc.authorscopusid23502381000
dc.authorscopusid23027537500
dc.authorscopusid6701789599
dc.authorscopusid6603903192
dc.authorscopusid6603339039
dc.authorscopusid6603339039
dc.contributor.authorBalaydiin, H.T.
dc.contributor.authorSöyüt, H.
dc.contributor.authorEkinci, D.
dc.contributor.authorGöksu, S.
dc.contributor.authorBeydemir, S.
dc.contributor.authorMenzek, A.
dc.contributor.authorŞahin, E.
dc.date.accessioned2020-06-21T14:28:12Z
dc.date.available2020-06-21T14:28:12Z
dc.date.issued2012
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Balaydiin] Halis Türker, Department of Chemistry, Atatürk Üniversitesi, Erzurum, Erzurum, Turkey, Department of Primary Education, Artvin Coruh University, Artvin, Artvin, Turkey; [Söyüt] Hakan, Department of Chemistry, Atatürk Üniversitesi, Erzurum, Erzurum, Turkey, Department of Elementary Science Education, Bayburt Üniversitesi, Bayburt, Bayburt, Turkey; [Ekinci] Deniz, Department of Agricultural Biotechnology, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Göksu] Süleyman, Department of Chemistry, Atatürk Üniversitesi, Erzurum, Erzurum, Turkey; [Beydemir] Şükrü, Department of Chemistry, Atatürk Üniversitesi, Erzurum, Erzurum, Turkey, Biotechnology Application and Research Center, Atatürk Üniversitesi, Erzurum, Erzurum, Turkey; [Menzek] Abdullah Elah, Department of Chemistry, Atatürk Üniversitesi, Erzurum, Erzurum, Turkey; [Şahin] Ertan, Department of Chemistry, Atatürk Üniversitesi, Erzurum, Erzurum, Turkeyen_US
dc.description.abstract(2-Bromo-3,4-dimethoxyphenyl) (3,4-dimethoxyphenyl)methanone (10) and its derivatives with Br, one dibromide and isomeric three tribromides, were synthesized. Demethylation of these compounds afforded a series of new bromophenols. Inhibition of human cytosolic carbonic anhydrase II (hCA II) isozyme by these new bromophenols and naturally occurring 3,4,6-tribromo-5-(2,5- dibromo-3,4-dihydroxybenzyl)benzene-1,2-diol (3), and 5,5′-methylenebis(3, 4,6-tribromo-benzene-1,2-diol) (4) was investigated. The synthesized compounds showed carbonic anhydrase inhibitory capacities with IC <inf>50</inf> values in the range of 0.7372 μM against hCA II. Some bromophenols investigated here showed effective hCA II inhibitory activity and might be used as leads for generating novel carbonic anhydrase inhibitors which are valuable drug candidates for the treatment of glaucoma, epilepsy, gastric and duodenal ulcers, neurological disorders, or osteoporosis. © 2012 Informa UK, Ltd.en_US
dc.identifier.doi10.3109/14756366.2011.574131
dc.identifier.endpage50en_US
dc.identifier.issn1475-6366
dc.identifier.issn1475-6374
dc.identifier.issue1en_US
dc.identifier.pmid21635211
dc.identifier.scopus2-s2.0-79959914230
dc.identifier.scopusqualityQ1
dc.identifier.startpage43en_US
dc.identifier.urihttps://doi.org/10.3109/14756366.2011.574131
dc.identifier.volume27en_US
dc.identifier.wosWOS:000298748800008
dc.identifier.wosqualityQ1
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Enzyme Inhibition and Medicinal Chemistryen_US
dc.relation.journalJournal of Enzyme Inhibition and Medicinal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBromophenolsen_US
dc.subjectCarbonic Anhydraseen_US
dc.subjectDiphenylmethaneen_US
dc.subjectEnzyme Inhibitionen_US
dc.subjectGlaucomaen_US
dc.titleSynthesis and Carbonic Anhydrase Inhibitory Properties of Novel Bromophenols Including Natural Productsen_US
dc.typeArticleen_US
dspace.entity.typePublication

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