Use of GnRH Agonist (Desloreline) in Combination with PGF2α on the Termination of Pregnancy in Bitches

Abstract

Ten bitches whose sexual cycle periods were determined with vaginal cytology to be mated at appropriate time were used in this study. Desloreline implant (Suprelorin (R)) was inserted under the dorsal skin of bitches that were determined to be pregnant using ultrasonography 20 days after the first day of mating. Ten days after the implant insertion, single dose PGF(2 alpha) (cloprostenol, 20 mu g/kg, IM) was administered. The pregnancy was terminated on all bitches that received this procedure. It was determined that the level of progesterone decreased from an average of 28.87 +/- 11.86 ng/ml on the day of implant insertion (day 20-21 of pregnancy) to 0.43 +/- 0.31 ng/ml when the abortion was completed. It was observed that after the implant insertion, the abortion was completed in an average of 3.9 +/- 0.7 days following PGF(2 alpha) administration. It has been observed that abortions was completed in an average of 2,3 +/- 0.48 days after the first vaginal discharge was seen. In conclusion, it was determined that Desloreline, a GnRH agonist, successfully could terminate pregnancy when it is combined with a single dose of PGF(2 alpha) administration in bitches.