Synthesis, Characterization, Structures and Cytotoxic Activity of Palladium(II) and Platinum(II) Complexes Containing Bis(2-Pyridylmethyl)amine and Saccharinate

Abstract

New palladium(II) and platinum(II) complexes containing bis(2-pyridylmethyl)amine (bpma) and saccharinate (sac), [Pd(bpma)(sac)](sac) ·2H<inf>2</inf>O (1), [Pt(bpma)(sac)](sac)·2H<inf>2</inf>O (2), [Pd(bpma)Cl](sac)·2H<inf>2</inf>O (3) and [Pt(bpma)(sac)]Cl·1. 5H<inf>2</inf>O (4), were synthesized and characterized by elemental analysis, IR, NMR and TG-DTA. A single-crystal X-ray analysis of 3 and 4 proved a distorted square-planar geometry around the metal ions with one tridentate bpma ligand and one Cl or sac monoanion. The [Pd(bpma)Cl]+ ions in 3 form dimers by intermolecular N-H⋯Cl and Pd⋯Pd interactions. The cations reside in the centers of a hydrogen-bonded honeycomb network formed by the uncoordinated sac ions and the lattice water molecules, while the cations of 4 are connected by N-H⋯Cl and OW-H⋯O hydrogen bonds into one-dimensional chains. Cyclic planar tetrameric and trimeric water clusters were observed in 3 and 4, respectively. Cytotoxicity of 1-4 was tested against A549, C6 and CHO cells. Although 2 and 4 have no cytotoxicity, the best results were achieved for 1 and 3. In particular, the cyctotoxic activity of 3 is comparable to cisplatin. © 2010 Elsevier Ltd. All rights reserved.