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The Effect of Alpha-Tocopherol in the Acute Ethanol Intake and Its Withdrawal on Penicillin-Induced Epilepsy

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dc.authorscopusid15048386900
dc.authorscopusid6602693377
dc.authorscopusid57207157391
dc.authorscopusid7003281190
dc.contributor.authorKozan, R.
dc.contributor.authorAyyildiz, M.
dc.contributor.authorYildirim, M.
dc.contributor.authorAǧar, E.
dc.date.accessioned2020-06-21T15:07:37Z
dc.date.available2020-06-21T15:07:37Z
dc.date.issued2009
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Kozan] Ramazan, Department of Physiology, Ondokuz Mayis University, Medical School, Samsun, Turkey; [Ayyildiz] Mustafa, Department of Physiology, Ondokuz Mayis University, Medical School, Samsun, Turkey; [Yildirim] Mehmet Iskender, Department of Physiology, Ondokuz Mayis University, Medical School, Samsun, Turkey; [Aǧar] Erdal, Department of Physiology, Ondokuz Mayis University, Medical School, Samsun, Turkeyen_US
dc.description.abstractThe present study was designed to investigate the influence of acute ethanol intake and its withdrawal on the anticonvulsant effect of alpha-tocopherol in penicillin-induced epileptiform activity. Ethanol-treated rats received a daily dose of 3 g/kg or 9.0 g/kg of 30% ethanol solution for 3 days. Thirty minutes after penicillin injection (500 units, i.c.), the most effective dose of alpha-tocopherol (500 mg/kg) was administered intramuscularly (i.m.). Acute administration of ethanol, in a dose of 3 g/ kg, did not change either frequency or amplitude of penicillin-induced epileptiform activity, while dose of 9 g/kg ethanol significantly decreased the mean frequency of penicillin-induced epileptiform ECoG activity in the ethanol-treated group. Ethanol (9 g/kg) withdrawal also caused an increase in the amplitude of epileptiform ECoG activity in the withdrawal group. The results suggest that acute administration of high dose ethanol (9 g/kg) and alpha-tocopherol have some limited anticonvulsive effects in penicillin-induced epileptiform activity in rats. © 2009 by Polish Neuroscience Society - PTBUN, Nencki Institute of Experimental Biology.en_US
dc.identifier.doi10.55782/ane-2009-1743
dc.identifier.endpage188en_US
dc.identifier.issn0065-1400
dc.identifier.issn1689-0035
dc.identifier.issue2en_US
dc.identifier.pmid19593332
dc.identifier.scopus2-s2.0-70349252861
dc.identifier.scopusqualityQ3
dc.identifier.startpage177en_US
dc.identifier.urihttps://doi.org/10.55782/ane-2009-1743
dc.identifier.volume69en_US
dc.identifier.wosWOS:000268022900003
dc.identifier.wosqualityQ4
dc.language.isoenen_US
dc.publisherNencki Institute of Experimental Biologyen_US
dc.relation.ispartofActa Neurobiologiae Experimentalisen_US
dc.relation.journalActa Neurobiologiae Experimentalisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcuteen_US
dc.subjectAlpha-Tocopherolen_US
dc.subjectECOGen_US
dc.subjectEpileptiform Activityen_US
dc.subjectEthanolen_US
dc.subjectPenicillinen_US
dc.titleThe Effect of Alpha-Tocopherol in the Acute Ethanol Intake and Its Withdrawal on Penicillin-Induced Epilepsyen_US
dc.typeArticleen_US
dspace.entity.typePublication

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