Publication:
Higher COVID-19 Pneumonia Risk Associated with Anti-IFN Than with Anti-IFN Auto-Abs in Children

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dc.authorscopusid57219618314
dc.authorscopusid57222020896
dc.authorscopusid57221963011
dc.authorscopusid57218864221
dc.authorscopusid57253722400
dc.authorscopusid58681065900
dc.authorscopusid7102320502
dc.contributor.authorBastard, P.
dc.contributor.authorGervais, A.
dc.contributor.authorTaniguchi, M.
dc.contributor.authorSaare, L.
dc.contributor.authorSärekannu, K.
dc.contributor.authorVoyer, T.L.
dc.contributor.authorPhilippot, Q.
dc.date.accessioned2025-12-11T00:33:26Z
dc.date.issued2024
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Bastard] Paul, Laboratory of Human Genetics of Infectious Diseases, Hôpital Necker Enfants Malades, Paris, France, Université Paris Cité, Paris, Ile-de-France, France, St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller University, New York, NY, United States, Pediatric Hematology-Immunology and Rheumatology Unit, Hôpital Necker Enfants Malades, Paris, France, Université Sorbonne Paris Cité, Paris, Ile-de-France, France; [Gervais] Adrian, Laboratory of Human Genetics of Infectious Diseases, Hôpital Necker Enfants Malades, Paris, France, Université Paris Cité, Paris, Ile-de-France, France; [Taniguchi] Maki, Department of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Hiroshima, Japan; [Saare] Liisa, Department of Pediatrics, Tartu Ülikool, Tartu, Tartumaa, Estonia; [Särekannu] Karita, Molecular Pathology, Tartu Ülikool, Tartu, Tartumaa, Estonia; [Voyer] Tom Le, Laboratory of Human Genetics of Infectious Diseases, Hôpital Necker Enfants Malades, Paris, France, Université Paris Cité, Paris, Ile-de-France, France; [Philippot] Quentin, Laboratory of Human Genetics of Infectious Diseases, Hôpital Necker Enfants Malades, Paris, France, Université Paris Cité, Paris, Ile-de-France, France; [Rosain] Jérémie, Laboratory of Human Genetics of Infectious Diseases, Hôpital Necker Enfants Malades, Paris, France, Université Paris Cité, Paris, Ile-de-France, France; [Bizien] Lucy, Laboratory of Human Genetics of Infectious Diseases, Hôpital Necker Enfants Malades, Paris, France, Université Paris Cité, Paris, Ile-de-France, France; [Asano] Takaki, Department of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Hiroshima, Japan; [Garcia-Prat] Marina, Pediatric Infectious Diseases and Immunodeficiencies Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain; [Parra-Martinez] Alba, Pediatric Infectious Diseases and Immunodeficiencies Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain; [Migaud] Mélanie, Laboratory of Human Genetics of Infectious Diseases, Hôpital Necker Enfants Malades, Paris, France, Université Paris Cité, Paris, Ile-de-France, France; [Tsumura] Miyuki, Department of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Hiroshima, Japan; [Conti] Francesca, Pediatric Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, BO, Italy, Department of Medical and Surgical Sciences, Alma Mater Studiorum Università di Bologna, Bologna, BO, Italy; [Belot] Alexandre, and Autoimmune and Systemic Diseases in Children, National Reference Center for Rheumatic, Lyon, France, Immunopathology Federation LIFE, CHU de Lyon, Lyon, Auvergne-Rhone-Alpes, France, CHU de Lyon, Lyon, Auvergne-Rhone-Alpes, France, École Normale Supérieure de Lyon, Lyon, Auvergne-Rhone-Alpes, France, Pediatric Nephrology Unit, Université de Lyon, Lyon, Auvergne-Rhone-Alpes, France; [Rivière] Jacques G., Pediatric Infectious Diseases and Immunodeficiencies Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain; [Morio] Tomohiro, Department of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Tokyo, Japan, Institute of Science Tokyo Hospital, Tokyo, Japan; [Tanaka] Junko, Department of Epidemiology, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Hiroshima, Japan; [Javouhey] Étienne, Pediatric Intensive Care Unit, CHU de Lyon, Lyon, Auvergne-Rhone-Alpes, France; [Haerynck] Filomeen, Department of Paediatric Immunology and Pulmonology, Universitair Ziekenhuis Gent, Ghent, VOV, Belgium, Department of Paediatric Immunology and Pulmonology, Universitair Ziekenhuis Gent, Ghent, VOV, Belgium; [Duvlis] Sotirija, Faculty of Medical Sciences, Goce Delcev University, Stip, North Macedonia, Institute of Public Health of the Republic of North Macedonia, Skopje, North Macedonia; [Ozcelik] Tayfun, Department of Molecular Biology and Genetics, Bilkent Üniversitesi, Ankara, Ankara, Turkey, Department of Molecular Biology and Genetics, Bilkent Üniversitesi, Ankara, Ankara, Turkey; [Keles] Sevgi, Meram Medical Faculty, Necmettin Erbakan Üniversitesi, Meram, Konya, Turkey; [Tandjaoui-Lambiotte] Yacine, Pulmonology and Infectious Disease Department, Saint-Denis Hospital, Saint-Denis, Réunion, France, Infection, Anti-Microbien, Modélisation, Évolution, Paris, Ile-de-France, France, Hypoxie & Poumon (H&P), Bobigny, Ile-de-France, France; [Escoda] Simon, Department of Pediatrics, Saint-Denis Hospital, Saint-Denis, Réunion, France; [Husain] Maya, Department of Pediatrics, Saint-Denis Hospital, Saint-Denis, Réunion, France; [Pan-Hammarström] Qiang, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Stockholms, Sweden, Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Stockholms, Sweden; [Hammarström] Lennart L.G., Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Stockholms, Sweden, Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Stockholms, Sweden; [Ahlijah] Gloria, Laboratory of Human Genetics of Infectious Diseases, Hôpital Necker Enfants Malades, Paris, France; [Haidar] Anthony Abi, Laboratory of Human Genetics of Infectious Diseases, Hôpital Necker Enfants Malades, Paris, France; [Soudee] Camille, Laboratory of Human Genetics of Infectious Diseases, Hôpital Necker Enfants Malades, Paris, France; [Arseguel] Vincent, Laboratory of Human Genetics of Infectious Diseases, Hôpital Necker Enfants Malades, Paris, France; [Abolhassani] Hassan, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Stockholms, Sweden, Pediatrics Center of Excellence, Research Center for Immunodeficiencies, Tehran, Tehran, Iran; [Sahanic] Sabina, Department of Internal Medicine, Medizinische Universitat Innsbruck, Innsbruck, Tyrol, Austria; [Tancevski] Ivan, Department of Internal Medicine, Medizinische Universitat Innsbruck, Innsbruck, Tyrol, Austria, Department of Internal Medicine, Medizinische Universitat Innsbruck, Innsbruck, Tyrol, Austria; [Nukui] Yoko, Department of Infection Control and Prevention, Institute of Science Tokyo, Tokyo, Japan; [Hayakawa] Seiichi, Department of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Hiroshima, Japan; [Chrousos] George P., National and Kapodistrian University of Athens, Athens, Attica, Greece; [Michos] Athanasios G., National and Kapodistrian University of Athens, Athens, Attica, Greece, First Dept. of Pediatics, National and Kapodistrian University of Athens, Athens, Attica, Greece; [Tatsi] Elizabeth Barbara, National and Kapodistrian University of Athens, Athens, Attica, Greece, First Dept. of Pediatics, National and Kapodistrian University of Athens, Athens, Attica, Greece; [Filippatos] Filippos, National and Kapodistrian University of Athens, Athens, Attica, Greece, First Dept. of Pediatics, National and Kapodistrian University of Athens, Athens, Attica, Greece; [Rodríguez-Palmero Seuma] Agustí, Neurometabolic Diseases Laboratory, Institut d'Investigació Biomedica de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain, UAB, Hospital Universitari Germans Trias i Pujol, Badalona, Spain, Centro de Investigación Biomédica en Red de Enfermedades Raras, Madrid, Madrid, Spain; [Troya] Jesus, Department of Internal Medicine, Hospital Universitario Infanta Leonor, Madrid, Madrid, Spain; [Tipu] Imran, University of Management and Technology Lahore, Lahore, Pakistan; [Meyts] Isabelle, Department of Immunology, KU Leuven, Leuven, Vlaams-Brabant, Belgium, Department of Pediatrics, KU Leuven– University Hospital Leuven, Leuven, Vlaams-Brabant, Belgium, Department of Pediatrics, KU Leuven– University Hospital Leuven, Leuven, Vlaams-Brabant, Belgium, Departement Microbiologie, Immunologie en Transplantatie, Leuven, Vlaams-Brabant, Belgium, Laboratory for Inborn Errors of Immunity, KU Leuven, Leuven, Vlaams-Brabant, Belgium; [Roussel] Lucie, Department of Medicine, Centre Universitaire de Santé McGill, Montreal, QC, Canada, Infectious Disease Susceptibility Program, L'Institut de Recherche du Centre Universitaire de Santé McGill, Montreal, QC, Canada; [Ostrowski] Sisse Rye, Department of Clinical Immunology, Rigshospitalet, Copenhagen, Hovedstaden, Denmark; [Schidlowski] Laire, Faculdades Pequeno Príncipe, Curitiba, PR, Brazil; [Prando] Carolina, Faculdades Pequeno Príncipe, Curitiba, PR, Brazil; [Condino‑Neto] Antonio A., Department of Immunology, Universidade de São Paulo, Sao Paulo, SP, Brazil, Department of Immunology, Universidade de São Paulo, Sao Paulo, SP, Brazil; [Cheikh] Nathalie, Pediatric Hematology Unit, Centre Hospitalier Universitaire de Besançon, Besancon, Bourgogne-Franche-Comte, France; [Bousfiha] Ahmed Aziz, Inflammation et Allergie, Centre Hospitalier Universitaire Ibn Rochd, Casablanca, Casablanca-Settat, Morocco, Inflammation et Allergie, Centre Hospitalier Universitaire Ibn Rochd, Casablanca, Casablanca-Settat, Morocco; [Bakkouri] Jalila El, Inflammation et Allergie, Centre Hospitalier Universitaire Ibn Rochd, Casablanca, Casablanca-Settat, Morocco; [Peterson] Pärt, Molecular Pathology, Tartu Ülikool, Tartu, Tartumaa, Estonia; [Pujol] Aurora, Neurometabolic Diseases Laboratory, Hospital Duran i Reynals, Barcelona, Barcelona, Spain, Neurometabolic Diseases Laboratory, Hospital Universitari de Bellvitge, Barcelona, Barcelona, Spain, Institució Catalana de Recerca i Estudis Avançats, Barcelona, Barcelona, Spain, Centro de Investigación Biomédica en Red de Enfermedades Raras, Madrid, Madrid, Spain; [Levy] Romain, Laboratory of Human Genetics of Infectious Diseases, Hôpital Necker Enfants Malades, Paris, France, Université Paris Cité, Paris, Ile-de-France, France, Pediatric Hematology-Immunology and Rheumatology Unit, Hôpital Necker Enfants Malades, Paris, France; [Quartier] Pierre Marie, Université Paris Cité, Paris, Ile-de-France, France, Pediatric Hematology-Immunology and Rheumatology Unit, Hôpital Necker Enfants Malades, Paris, France; [Vinh] Donald C., Department of Medicine, Centre Universitaire de Santé McGill, Montreal, QC, Canada, Infectious Disease Susceptibility Program, L'Institut de Recherche du Centre Universitaire de Santé McGill, Montreal, QC, Canada, Department of Medicine, Centre Universitaire de Santé McGill, Montreal, QC, Canada, Infectious Disease Susceptibility Program, L'Institut de Recherche du Centre Universitaire de Santé McGill, Montreal, QC, Canada; [Boisson] Bertrand, Laboratory of Human Genetics of Infectious Diseases, Hôpital Necker Enfants Malades, Paris, France, Université Paris Cité, Paris, Ile-de-France, France, St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller University, New York, NY, United States; [Béziat] Vivien, Laboratory of Human Genetics of Infectious Diseases, Hôpital Necker Enfants Malades, Paris, France, Université Paris Cité, Paris, Ile-de-France, France, St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller University, New York, NY, United States; [Zhang] Shenying, Laboratory of Human Genetics of Infectious Diseases, Hôpital Necker Enfants Malades, Paris, France, Université Paris Cité, Paris, Ile-de-France, France, St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller University, New York, NY, United States, Université Sorbonne Paris Cité, Paris, Ile-de-France, France; [Borghesi] Alessandro, Neonatal Intensive Care Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, PV, Italy; [Pession] Andrea, Pediatric Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, BO, Italy; [Andreakos] Evangelos Th, Center for Clinical, Academy of Athens, Athens, Attica, Greece; [Marr] Nico, Sidra Medicine, Doha, Qatar; [Mentis] Alexios Fotios A., National and Kapodistrian University of Athens, Athens, Attica, Greece; [H.mogensen] Trine, Department of Infectious Diseases, Aarhus Universitetshospital, Aarhus, Midtjylland, Denmark, Department of Biomedicine, Aarhus Universitet, Aarhus, Midtjylland, Denmark; [Rodríguez-Gallego] Carlos, Hospital de Gran Canaria Dr. Negrin, Las Palmas de Gran Canaria, Las Palmas, Spain, Department of Clinical Sciences, Universidad Fernando Pessoa Canarias, Santa Maria de Guia de Gran Canaria, Las Palmas, Spain, Department of Medical and Surgical Sciences, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Canary Islands, Spain, Department of Immunology, Hospital de Gran Canaria Dr. Negrin, Las Palmas de Gran Canaria, Las Palmas, Spain, Department of Clinical Sciences, Universidad Fernando Pessoa Canarias, Santa Maria de Guia de Gran Canaria, Las Palmas, Spain; [Soler-Palacín] P., Pediatric Infectious Diseases and Immunodeficiencies Unit, Vall d'Hebron Institut de Recerca, Barcelona, Spain; [Colobran Oriol] Roger, UAB, Vall d'Hebron Institut de Recerca, Barcelona, Spain, UAB, Vall d'Hebron Institut de Recerca, Barcelona, Spain; [Tillmann] Vallo, Department of Pediatrics, Tartu Ülikool, Tartu, Tartumaa, Estonia; [Neven] Bénédicte, Université Paris Cité, Paris, Ile-de-France, France, Pediatric Hematology-Immunology and Rheumatology Unit, Hôpital Necker Enfants Malades, Paris, France; [Trouillet-Assant] Sophie, CHU de Lyon, Lyon, Auvergne-Rhone-Alpes, France, École Normale Supérieure de Lyon, Lyon, Auvergne-Rhone-Alpes, France, Joint Research Unit, CHU de Lyon, Lyon, Auvergne-Rhone-Alpes, France, École Normale Supérieure de Lyon, Lyon, Auvergne-Rhone-Alpes, France; [Brodin] Petter, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Stockholms, Sweden, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Stockholms, Sweden; [Abel] Laurent, Laboratory of Human Genetics of Infectious Diseases, Hôpital Necker Enfants Malades, Paris, France, Université Paris Cité, Paris, Ile-de-France, France, St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller University, New York, NY, United States, Université Sorbonne Paris Cité, Paris, Ile-de-France, France; [Jouanguy] Emmanuelle, Laboratory of Human Genetics of Infectious Diseases, Hôpital Necker Enfants Malades, Paris, France, Université Paris Cité, Paris, Ile-de-France, France, St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller University, New York, NY, United States, Université Sorbonne Paris Cité, Paris, Ile-de-France, France; [Zhang] Qian, Laboratory of Human Genetics of Infectious Diseases, Hôpital Necker Enfants Malades, Paris, France, Université Paris Cité, Paris, Ile-de-France, France, St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller University, New York, NY, United States, Université Sorbonne Paris Cité, Paris, Ile-de-France, France; [Martinón-Torres] Federico, Department of Pediatrics, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain, GENVIP Research Group, Universidade de Santiago de Compostela, Santiago de Compostela, A Coruna, Spain, Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Madrid, Madrid, Spain, Department of Pediatrics, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Salas] Antonio, Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Madrid, Madrid, Spain, GenPoB Research Group, Universidade de Santiago de Compostela, Santiago de Compostela, A Coruna, Spain, Departamento de Anatomía Patolóxica e Ciencias Forenses, Facultade de Veterinaria, Lugo, Lugo, Spain; [Gómez-Carballa] Alberto, GENVIP Research Group, Universidade de Santiago de Compostela, Santiago de Compostela, A Coruna, Spain, Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Madrid, Madrid, Spain, GenPoB Research Group, Universidade de Santiago de Compostela, Santiago de Compostela, A Coruna, Spain; [González-Granado] Luis Ignacio, Immunodeficiencies Unit, Hospital Universitario 12 de Octubre, Madrid, Madrid, Spain; [Kisand] Kai E., Molecular Pathology, Tartu Ülikool, Tartu, Tartumaa, Estonia, Molecular Pathology, Tartu Ülikool, Tartu, Tartumaa, Estonia; [Okada] Satoshi, Department of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Hiroshima, Japan, Department of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Hiroshima, Japan; [Puel] Anne, Laboratory of Human Genetics of Infectious Diseases, Hôpital Necker Enfants Malades, Paris, France, Université Paris Cité, Paris, Ile-de-France, France, St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller University, New York, NY, United States, Université Sorbonne Paris Cité, Paris, Ile-de-France, France; [Cobat] Aurélie, Laboratory of Human Genetics of Infectious Diseases, Hôpital Necker Enfants Malades, Paris, France, Université Paris Cité, Paris, Ile-de-France, France, St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller University, New York, NY, United States, Université Sorbonne Paris Cité, Paris, Ile-de-France, France; [Casanova] Jean Laurent, Laboratory of Human Genetics of Infectious Diseases, Hôpital Necker Enfants Malades, Paris, France, Université Paris Cité, Paris, Ile-de-France, France, St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller University, New York, NY, United States, Howard Hughes Medical Institute, Chevy Chase, MD, United States, Department of Pediatrics, Hôpital Necker Enfants Malades, Paris, France, Rockefeller University, New York, NY, United States, Hôpital Necker Enfants Malades, Paris, France; [Aguilera-Albesa] Sergio, Navarra Health Service Hospital, Pamplona, Spain; [AlKhater] Suzan A., Department of Pediatrics, King Fahd Hospital of the University, Al-Khobar, Ash Sharqiyah, Saudi Arabia, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Ash Sharqiyah, Saudi Arabia; [Alkan] Gülsüm, Selçuk Tip Fakültesi, Konya, Turkey; [Castagnoli] Riccardo, Surgical, Università degli Studi di Pavia, Pavia, PV, Italy, Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, PV, Italy; [Cyrus] Cyril, Department of Biochemistry, Imam Abdulrahman Bin Faisal University, Dammam, Ash Sharqiyah, Saudi Arabia; [Bozdemir] Şefika Elmas, Bursa City Hospital, Bursa, Bursa, Turkey; [Emiroǧlu] Melike Keser, Selçuk Tip Fakültesi, Konya, Turkey; [Gülhan] Belgin, Children's Hospital, Ankara, Ankara, Turkey; [Erdeniz] Emine Hafize, Ondokuz Mayis University, Medical School, Samsun, Turkey; [Hatipoǧlu] Nevin, Pediatric Infectious Diseases Unit, University of Health Sciences, Istanbul, Turkey; [Bayhan] Gülsüm İclal, Faculty of Medicine, Ankara Yildirim Beyazit University, Ankara, Turkey; [Jabandžiev] Petr, Fakultni Nemocnice Brno, Brno, South Moravian Region, Czech Republic; [Kanik-Yüksek] Saliha, University of Health Sciences, Istanbul, Turkey; [Karbuz] Adem, Cemil Taşçıoğlu City Hospital, Istanbul, Istanbul, Turkey; [Tuter Oz] Sadiye Kübra, Selçuk Tip Fakültesi, Konya, Turkey; [Marseglia] Gian Luigi, Surgical, Università degli Studi di Pavia, Pavia, PV, Italy, Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, PV, Italy; [Akcan] Ozge Metin, Meram Medical Faculty, Necmettin Erbakan Üniversitesi, Meram, Konya, Turkey; [Kılıç] Ahmet Osman, Meram Medical Faculty, Necmettin Erbakan Üniversitesi, Meram, Konya, Turkey; [Özkaya-Parlakay] Aslinur Inur, Children's Hospital, Ankara, Ankara, Turkey; [Papadaki] Maria, Center for Clinical, Academy of Athens, Athens, Attica, Greece; [Slabá] Kateřina, Fakultni Nemocnice Brno, Brno, South Moravian Region, Czech Republic; [Sevketoglu] Esra, Intensive Care Unit, University of Health Sciences, Istanbul, Turkey; [Valencia-Ramos] Juan, Complejo Asistencial Universitario de Burgos, Burgos, Burgos, Spain; [Yahśi] Aysun, Children's Hospital, Ankara, Ankara, Turkey; [Tuala] Currás, Department of Pediatrics, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Urbieta] Ana Dacosta, Department of Pediatrics, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Esteban] Blanca Díaz, Department of Pediatrics, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Domínguez-Santalla] Maria Jesus, Service of Internal Medicine, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Pérez] Cristina Fernández, Preventive Medicine Unit, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Villaverde] Juan Fernández, Intensive Care Service, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Rodríguez] Cristóbal Galbán, Intensive Care Service, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Allut] José Luis García, Intensive Care Service, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Vicente] Luisa García, Department of Pediatrics, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Vázquez] Elena Giráldez, Intensive Care Service, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Carballa] Alberto Gómez, Department of Pediatrics, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Rial] José Gómez, Department of Pediatrics, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Barcala] Francisco Javier González, Service of Pneumology, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Liñares] Beatriz Guerra, Preventive Medicine Unit, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Iglesias] Pilar Leboráns, Department of Pediatrics, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Massa] Beatriz Lence, Intensive Care Service, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Fuentes] Marta Lendoiro, Department of Pediatrics, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Franco] Montserrat López, Department of Pediatrics, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Lago] Ana López, Intensive Care Service, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Cruz] Daniel Navarro De La, Service of Microbiology, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Masid] Eloína Núñez, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Devesa] Juan Bautista Ortolá, Clinical Chemistry Laboratory, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Seco] Jacobo Pardo, Department of Pediatrics, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Nuñez] María Pazo, Service of Internal Medicine, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Bernal] Marisa Pérez Del Molino, Service of Microbiology, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Freixo] Hugo Pérez, Preventive Medicine Unit, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Rodríguez] Lidia Piñeiro, Department of Pediatrics, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Pischedda] Sara, Department of Pediatrics, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Portela Romero] Manuel, Pharmaceutical Delivery, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Reino] Antonio Pose, Service of Internal Medicine, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Hervella] Gloria María Prada, Anesthesiology and Resuscitation Service, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Verdes] Teresa Queiro, Preventive Medicine Unit, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Collazo] Lorenzo Redondo, Department of Pediatrics, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Casuso] Patricia Regueiro, Department of Pediatrics, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [García] Susana Rey, Department of Pediatrics, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Vázquez] Sara Rey, Department of Pediatrics, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Blanco] Vanessa Riveiro, Service of Pneumology, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Calle] Irene Rivero, Department of Pediatrics, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Velasco] Carmen Rivero, Intensive Care Service, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Núñez] Nuria Rodríguez, Service of Pneumology, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Sánchez] Carmen Rodríguez Tenreiro, Department of Pediatrics, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Paz] Eva Saborido, Intensive Care Service, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Orayyou] José Miguel Sadiki, Department of Pediatrics, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Villanueva] Carla Saito, Intensive Care Service, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Fernández] Sonia Serén, Department of Pediatrics, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Sanmartín] Pablo Souto, Preventive Medicine Unit, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Muñiz] Manuel Taboada, Anesthesiology and Resuscitation Service, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Pena] Rocío Trastoy, Service of Microbiology, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Castellano] Mercedes Treviño, Service of Microbiology, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Cuadrado] Luis Valdés, Service of Pneumology, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [García] Pablo Varela, Service of Internal Medicine, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Iglesias] Maria Soledad Vilas, Department of Pediatrics, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Lasheras] Sandra Viz, Department of Pediatrics, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Ferreiro-Iglesias] Rocío, Digestive Service, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Baston-Rey] Iria, Digestive Service, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Calviño-Suárez] Cristina, Digestive Service, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Galicia, Spain; [Aïuti] Alessandro, Università Vita-Salute San Raffaele, Milan, MI, Italy; [Al-Muhsen] Saleh Zaid, Department of Pediatrics, College of Medicine, Riyadh, Riyad, Saudi Arabia; [Al-Mulla] F., Dasman Diabetes Institute, Dasman, Kuwait; [Amara] Ali, Genomes & Cell Biology of Disease Unit, Institut de Recherche Saint-Louis, Paris, Ile-de-France, France; [Anderson] Mark S., Diabetes Center, University of California, San Francisco, San Francisco, CA, United States; [Arias] Andrés Augusto, St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller University, New York, NY, United States, Department of Microbiology and Parasitology, Universidad de Antioquia, Medellin, Antioquia, Colombia, School of Microbiology, Universidad de Antioquia, Medellin, Antioquia, Colombia; [Arkin] Lisa M., Department of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States; [Feldman] Hagit Baris, Genetic Institute, Tel Aviv University, Tel Aviv-Yafo, Tel Aviv District, Israel; [Biggs] Catherine M., Department of Pediatrics, The University of British Columbia, Vancouver, BC, Canada; [Bogunovic] Dusan, Icahn School of Medicine at Mount Sinai, New York, NY, United States; [Bolze] Alexandre, Helix, San Mateo, CA, United States; [Bondarenko] Anastasia V., International European University, Kyiv, Kyiv Oblast, Ukraine; [Bryceson] Yenan Troi, Center for Hematology and Regenerative Medicine, Karolinska Institutet, Stockholm, Stockholms, Sweden; [Butte] Manish J., and Rheumatology, University of California, Los Angeles, Los Angeles, CA, United States; [Casari] Giorgio, Clinical Genomics, San Raffaele Scientific Institute, Milan, MI, Italy; [Christodoulou] John, Department of Paediatrics, Melbourne, VIC, Australia; [Constantinescu] Stefan N., Ludwig Institute for Cancer Research Brussels, Brussels, BRU, Belgium; [Cooper] Megan A., Washington University School of Medicine in St. Louis, St. Louis, MO, United States; [Dalgard] Clifton L., Department of Anatomy, Uniformed Services University of the Health Sciences, Bethesda, MD, United States; [Desai] Murkesh, Bai Jerbai Wadia Hospital for Children, Mumbai, MH, India; [Drolet] Beth Ann, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States; [Duval] Xavier, Université Paris Cité, Paris, Ile-de-France, France, Inserm, Paris, Ile-de-France, France; 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M., Research Unit, Hospital Universitario Nuestra Senora de Candelaria, Santa Cruz de Tenerife, Santa Cruz de Tenerife, Spain, Genomics Division, Instituto Tecnológico y de Energías Renovables, S.A., Granadilla de Abona, Santa Cruz de Tenerife, Spain, Faculty of Health Sciences, Universidad Fernando Pessoa Canarias, Santa Maria de Guia de Gran Canaria, Las Palmas, Spain; [Franco-Restrepo] José Luis, Group of Primary Immunodeficiencies, Universidad de Antioquia, Medellin, Antioquia, Colombia; [Froidure] Antoine, Pulmonology Department, Cliniques Universitaires Saint-Luc, Brussels, BRU, Belgium, Université Catholique de Louvain, Louvain-la-Neuve, WBR, Belgium; [Gorochov] Guy, Sorbonne Université, Paris, Ile-de-France, France; [Gregersen] Peter K., Feinstein Institute for Medical Research, Manhasset, NY, United States; [Grimbacher] Bodo, Center for Chronic Immunodeficiency & Institute for Immunodeficiency, Universitätsklinikum Freiburg, Freiburg im Breisgau, Baden-Wurttemberg, Germany; [Hagin] David, Tel Aviv Sourasky Medical Center, Tel Aviv-Yafo, Tel Aviv District, Israel; [Halwani] Rabih, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, Sharjah, United Arab Emirates, Immunology Research Laboratory, College of Medicine, Riyadh, Riyad, Saudi Arabia; [Heath] James R., Institute for Systems Biology, Seattle, WA, United States; [Hsieh] Elena Wen Yuan, Department of Microbiology and Immunology, University of Colorado School of Medicine, Aurora, CO, United States; [Husebye] Eystein Sverre, Department of Medicine, Haukeland Universitetssjukehus, Bergen, Hordaland, Norway; [Imai] Kohsuke, Perinatal and Maternal Medicine, Institute of Science Tokyo, Tokyo, Japan; [Itan] Yuval, Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States; [Jarvis] Erich D., Rockefeller University, New York, NY, United States; [Kaja] Elzbieta, Department of Medical Chemistry and Laboratory Medicine, Poznan University of Medical Sciences, Poznan, Wielkopolska Province, Poland; [Karamitros] Timokratis, Bioinformatics and Applied Genomics Unit, Hellenic Pasteur Institute, Athens, Attica, Greece; [Ku] Cheng-Lung, Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan; [Laen_US
dc.description.abstractWe found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients: IFN-α2 only in three, IFN-α2 plus IFN-ω in five, and IFN-α2, IFN-ω plus IFN-β in two; IFN-ω only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-α2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-ω in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-α2 only (OR [95% CI] = 67.6 [5.7–9,196.6]) than for auto-Abs neutralizing IFN-ω only (OR [95% CI] = 2.6 [1.2–5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6–35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1–9.6]) of IFN-ω and/or IFN-α2. © 2024, Rockefeller University Press. All rights reserved.en_US
dc.identifier.doi10.1084/jem.20231353
dc.identifier.issn0022-1007
dc.identifier.issn1540-9538
dc.identifier.issue2en_US
dc.identifier.pmid38175961
dc.identifier.scopus2-s2.0-85181628485
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1084/jem.20231353
dc.identifier.urihttps://hdl.handle.net/20.500.12712/37386
dc.identifier.volume221en_US
dc.identifier.wosqualityQ1
dc.language.isoenen_US
dc.publisherRockefeller University Pressen_US
dc.relation.ispartofJournal of Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCOVID-19en_US
dc.subjectImmunodeficiencyen_US
dc.subjectInfectious Disease and Host Defenseen_US
dc.subjectInnate Immunity and Inflammationen_US
dc.titleHigher COVID-19 Pneumonia Risk Associated with Anti-IFN Than with Anti-IFN Auto-Abs in Childrenen_US
dc.typeArticleen_US
dspace.entity.typePublication

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