Electrocatalytic Oxidation of Acyclovir on Poly(p-Aminobenzene Sulfonic Acid) Film Modified Glassy Carbon Electrode

Abstract

Acyclovir is an antiviral effective drug active compound. A glassy carbon electrode (GCE) was modified with an electropolymerized film of p-aminobenzene sulfonic acid (p-ABSA) in phosphate buffer solution (PBS). The polymer film-modified electrode was used to electrochemically detect acyclovir. Polymer film showed excellent electrocatalytic activity for the oxidation of acyclovir. The anodic peak potential value of the acyclovir at the poly(p-ABSA) modified glassy carbon electrode was 950mV obtained by DPV. A linear calibration curve for DPV analysis was constructed in the acyclovir concentration range 2×10-7-9×10-6molL-1. Limit of detection (LOD) and limit of quantification (LOQ) were obtained as 5.57×10-8 and 1.85×10-7molL-1 respectively. The proposed method exhibits good recovery and reproducibility. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.