The Effect of Tenoxicam on Histopathologic Healing of Penicillin G Induced Traumatic Sciatic Nerve Injury in Rats

Abstract

The aim of this study was to evaluate the histopathologic healing of penicillin G induced traumatic sciatic nerve injury with tenoxicam. 22-gauge sharp edged needle was inserted Into the sciatic nerve and 0.1 ml (25000 Ü) crystallized penicillin G was Injected. Rats were randomly divided into four groups. 1 ml intraperitoneal 0.09% NaCl solution was administered daily for one week in group I and for three weeks in group III. Group II and IV received 10 mg kg-1 tenoxicam in 1 ml volume intraperitoneally daily, for one week in group II and for three weeks in group IV. At the end of the trial sciatic nerve was explored and evaluated histopathologically in all groups. Perineural or neural healing of groups treated with serum physiologic or tenoxicam in one or three weeks were not statistically different. There was not statistically significant difference between groups, when neural and perineural healing was evaluated together. Anti-inflammatory drugs were not effective to obtain recovery after penicillin procaine induced injuries in the peripheral nerves, more research is needed for the effective management and treatment for sciatic nerve injury.