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Voltammetric Study of the Interaction of Pentoxifylline (PTX) With Zn(II) in the Presence and Absence of Cysteine

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dc.authorscopusid6603524165
dc.authorscopusid9335707800
dc.contributor.authorBi̇Çer, E.
dc.contributor.authorÇinar, E.
dc.date.accessioned2020-06-21T15:36:48Z
dc.date.available2020-06-21T15:36:48Z
dc.date.issued2005
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Bi̇Çer] Ender, Department of Chemistry, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Çinar] Elif, Department of Chemistry, Ondokuz Mayis Üniversitesi, Samsun, Turkeyen_US
dc.description.abstractThe interaction of pentoxifylline (PTX) with Zn(II) in the presence and absence of cysteine at physiological pH (7.40) was investigated for the first time by square-wave and cyclic voltammetry techniques. The Zn(II)-PTX complex was found to be an electroinactive inert complex, the composition of the formed complex is 1 : 1 (metal : ligand), and the logarithm of its stability constant (log β<inf>1:1</inf>) was determined as 3.46 by direct monitoring of the current of free zinc(II). The logarithm of the stability constant (log β<inf>1:2</inf>) and stoichiometry of the complexation of Zn(II) with cysteine were determined to be 9.94 and 1:2, respectively. The stability constants were in agreement with those calculated from electronic spectral data. In the presence of cysteine, Zn(II)-PTX dissociated and an irreversible peak for Zn(II)-cysteine appeared at -1.342V. Cysteine prevents complex formation of Zn(II) with PTX. © 2005 Taylor & Francis Group Ltd.en_US
dc.identifier.doi10.1080/00958970500092784
dc.identifier.endpage785en_US
dc.identifier.issn0095-8972
dc.identifier.issn1029-0389
dc.identifier.issue9en_US
dc.identifier.scopus2-s2.0-27944447615
dc.identifier.scopusqualityQ3
dc.identifier.startpage775en_US
dc.identifier.urihttps://doi.org/10.1080/00958970500092784
dc.identifier.volume58en_US
dc.identifier.wosWOS:000229817600006
dc.identifier.wosqualityQ3
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Coordination Chemistryen_US
dc.relation.journalJournal of Coordination Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCysteineen_US
dc.subjectPentoxifyllineen_US
dc.subjectVoltammetryen_US
dc.subjectZincen_US
dc.titleVoltammetric Study of the Interaction of Pentoxifylline (PTX) With Zn(II) in the Presence and Absence of Cysteineen_US
dc.typeArticleen_US
dspace.entity.typePublication

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