Publication:
Efficacy of Levamisole on Experimental Endometriosis

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dc.authorscopusid57196973990
dc.authorscopusid6701466395
dc.authorscopusid7006266820
dc.authorscopusid14032375600
dc.authorscopusid22934849400
dc.authorscopusid7003347267
dc.contributor.authorOcal, G.
dc.contributor.authorKökçü, A.
dc.contributor.authorÇetinkaya, M.B.
dc.contributor.authorTosun, M.
dc.contributor.authorKefeli, M.
dc.contributor.authorKandemír, B.
dc.date.accessioned2020-06-21T15:18:45Z
dc.date.available2020-06-21T15:18:45Z
dc.date.issued2007
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Ocal] G., Department of Obstetrics and Gynecology, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Kökçü] Arif, Department of Obstetrics and Gynecology, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Çetinkaya] Mehmet Bilge, Department of Obstetrics and Gynecology, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Tosun] Miǧraci, Department of Obstetrics and Gynecology, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Kefeli] Mehmet, Department of Pathology, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Kandemír] Bedri, Department of Pathology, Ondokuz Mayis Üniversitesi, Samsun, Turkeyen_US
dc.description.abstractObjective: To investigate the efficacy of levamisole on experimental endometriosis. Methods: After the implantation of endometrial tissue on abdominal peritoneum, 40 rats were randomized to 1 of 4 equal intervention groups. Levamisole (2 mg/rat) was applied subcutaneously to group "L" once a week. Depot medroxyprogesterone acetate (3 mg/kg) was applied intramuscularly to group "M" twice at 4-week intervals. Leuprolide (0.075 mg/kg) was applied subcutaneously to group "G" twice at 4-week intervals. Saline (0.1 cm3/rat) was applied subcutaneously to group "C" once a week for 8 weeks. The efficacy of levamisole was determined by volume measurement and characterizing the histological structure of the implants. Result: Volume increase of the implants in group C (P < 0.05), and volume decrease in groups M, G, and L was found (P < 0.05, P < 0.01, and P < 0.01, respectively.) Stromal tissue and glandular activity were not different between groups L and G. Conclusion: Levamisole was found to be as effective as leuprolide in regression of the volume of endometriotic implants. © 2007 International Federation of Gynecology and Obstetrics.en_US
dc.identifier.doi10.1016/j.ijgo.2007.04.041
dc.identifier.endpage42en_US
dc.identifier.issn0020-7292
dc.identifier.issn1879-3479
dc.identifier.issue1en_US
dc.identifier.pmid17678930
dc.identifier.scopus2-s2.0-34548321097
dc.identifier.scopusqualityQ1
dc.identifier.startpage38en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijgo.2007.04.041
dc.identifier.urihttps://hdl.handle.net/20.500.12712/19752
dc.identifier.volume99en_US
dc.identifier.wosWOS:000250017000013
dc.identifier.wosqualityQ2
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Ltden_US
dc.relation.ispartofInternational Journal of Gynecology & Obstetricsen_US
dc.relation.journalInternational Journal of Gynecology & Obstetricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEndometriosisen_US
dc.subjectLeuprolideen_US
dc.subjectLevamisoleen_US
dc.subjectMedroxyprogesterone Acetateen_US
dc.titleEfficacy of Levamisole on Experimental Endometriosisen_US
dc.typeArticleen_US
dspace.entity.typePublication

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