Publication:
Seizures with Pentylenetetrazol Kindling Cause a Decrease in the Number of Pyramidal Neurons in the Rat Hippocampus

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dc.authorscopusid57192891758
dc.authorscopusid23994048900
dc.authorscopusid56798472700
dc.authorscopusid15063935100
dc.authorscopusid56814477900
dc.authorscopusid6603762396
dc.authorscopusid6701737157
dc.contributor.authorKocacan, S.E.
dc.contributor.authorSefil, F.
dc.contributor.authorElibol, E.
dc.contributor.authorAltunkaynak, B.Z.
dc.contributor.authorAcar, M.D.
dc.contributor.authorBaǧirici, F.
dc.contributor.authorMarangoz, C.
dc.date.accessioned2025-12-10T23:17:46Z
dc.date.issued2016
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Kocacan] Süleyman Emre, Department of Physiology, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Sefil] Fatih, Department of Physiology, Mustafa Kemal Üniversitesi, Antakya, Turkey; [Elibol] Ebru, Department of Histology and Embryology, Adiyaman Üniversitesi, Adiyaman, Adiyaman, Turkey; [Altunkaynak] Berrin Zühal, Department of Histology and Embryology, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Acar] Meryem Dilek, Department of Physiology, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Baǧirici] Faruk, Department of Physiology, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Marangoz] Cafer, Department of Physiology, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Kaplan] Süleyman, Department of Histology and Embryology, Ondokuz Mayis Üniversitesi, Samsun, Turkeyen_US
dc.description.abstractOBJECTIVE: To investigate the effects of pentylenetetrazole (PTZ) kindling on the number of pyramidal neurons in the rat hippocampus. STUDY DESIGN: Using unbiased stereology, we calculated total pyramidal neuron numbers in the CA1, CA2, and CA3 areas and the whole hippocampus after PTZ-induced kindling. The estimation and the analysis of the number of hippocampal pyramidal cells (areas of CA1-3) were done with the optical fractionator technique, which is a stereological counting technique. RESULTS: Stereological analysis showed that the total number of pyramidal neurons in the whole hippocampus and the number of pyramidal neurons in CA1 were significantly lower in kindled rats as compared to the controls (p < 0.05). However, no significant difference was found in the neuron numbers of CA2 and CA3 (p>0.05). CONCLUSION: PTZ-induced seizures cause a decrease in the amount of pyramidal neurons in the CA area of the rat hippocampus. © Science Printers and Publishers, Inc.en_US
dc.identifier.endpage300en_US
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85008684365
dc.identifier.scopusqualityN/A
dc.identifier.startpage295en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12712/35331
dc.identifier.volume38en_US
dc.identifier.wosqualityN/A
dc.language.isoenen_US
dc.publisherScience Printers and Publishers Inc. Editor@acta-cytol.comen_US
dc.relation.ispartofAnalytical and Quantitative Cytopathology and Histopathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectConvulsantsen_US
dc.subjectEpilepsyen_US
dc.subjectKindling, Neurologicen_US
dc.subjectNeurological Disordersen_US
dc.subjectNeurotoxicityen_US
dc.subjectNeurotoxicity Syndromesen_US
dc.subjectNeurotoxin Diseasesen_US
dc.subjectPentylenetetrazoleen_US
dc.subjectSeizuresen_US
dc.subjectStereologyen_US
dc.titleSeizures with Pentylenetetrazol Kindling Cause a Decrease in the Number of Pyramidal Neurons in the Rat Hippocampusen_US
dc.typeArticleen_US
dspace.entity.typePublication

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