Publication:
Ovarian & Endometrial Cancers

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dc.authorscopusid56319544000
dc.authorscopusid6603432100
dc.contributor.authorTatar, B.
dc.contributor.authorGüneş, S.
dc.date.accessioned2025-12-11T00:22:33Z
dc.date.issued2020
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Tatar] Burak, Department of Gynecologic Oncology, University of Health Sciences, Istanbul, Turkey, Department of Multidisciplinary Molecular Medicine, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Güneş] Sezgin Özgür, Department of Multidisciplinary Molecular Medicine, Ondokuz Mayis Üniversitesi, Samsun, Turkey, Department of Medical Biology, Ondokuz Mayis University, Medical School, Samsun, Turkeyen_US
dc.description.abstractEndometrial and ovarian cancers are the most frequent and lethal gynecologic malignancies. These cancers have both genetic and epigenetic backgrounds like cancers in various tissues and organs. Genetic alterations lead to these tumors has been defined for a long time and continuing to be defined. Epigenetic modifications have also been suggested to play a significant role in various types of cancers including ovarian and endometrial cancers. Besides, epigenetic mechanisms are potentially reversible and that makes them attractive targets for treatment in comparison with DNA mutations. Therefore, this chapter introduces and reviews the role of epigenetic mechanisms in ovarian and endometrial cancers and summarizes the investigations of alterations in DNA methylation pattern including global and gene-specific methylation, role of histones, their modifications, and the function of ncRNAs in development and progression of those cancers. Additionally, epigenetic therapy alternatives for cancers ovarian and endometrial cancers are briefly discussed. © 2021 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/B978-0-12-819753-0.00016-7
dc.identifier.endpage341en_US
dc.identifier.isbn9780128197530
dc.identifier.scopus2-s2.0-85147598564
dc.identifier.startpage325en_US
dc.identifier.urihttps://doi.org/10.1016/B978-0-12-819753-0.00016-7
dc.identifier.urihttps://hdl.handle.net/20.500.12712/36230
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.publicationcategoryKitap Bölümü - Uluslararasıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectArten_US
dc.subjectDNA Methylationen_US
dc.subjectEndocannabinoidsen_US
dc.subjectEpigeneticsen_US
dc.subjectFolic Aciden_US
dc.subjectHistone Modificationen_US
dc.subjectImprintingen_US
dc.subjectMicroRNAen_US
dc.subjectTransgenerational Epigeneticsen_US
dc.titleOvarian & Endometrial Cancersen_US
dc.typeBook Parten_US
dspace.entity.typePublication

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