Publication:
Effects of Leontice Smirnowii Tuber Monodesmosides and Crude Extract in Carrageenan- and Histamine-Induced Acute Inflammation Model of Rats

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dc.authorscopusid7003758109
dc.authorscopusid6506378692
dc.authorscopusid8359291300
dc.authorscopusid7006549173
dc.contributor.authorGepdíremen, A.
dc.contributor.authorMshvildadze, V.
dc.contributor.authorBakuridze, K.
dc.contributor.authorElias, R.
dc.date.accessioned2020-06-21T15:25:12Z
dc.date.available2020-06-21T15:25:12Z
dc.date.issued2006
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Gepdíremen] Akçahan, Department of Pharmacology, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Mshvildadze] Vakhtang D., Institue of Pharmacochemistry, Georgian Academy of Sciences, Tbilisi, Georgia; [Bakuridze] Kakhi A., Department of Pharmacology, Tbilisi State Medical University, Tbilisi, Georgia; [Elias] Riad, Laboratory of Pharmacognosy and Homeopathy, Aix Marseille Université, Marseille, Provence-Alpes-Cote d'Azur, Franceen_US
dc.description.abstractLeontice smirnowii is a member of the Berberidaceae family. We have recently reported the 1,1-diphenyl-2-picryl-hydrazyl radical scavenging, superoxide anion radical scavenging, hydrogen peroxide scavenging, reducing power and metal chelating activities of L. smirnowii products. In the current study we investigated the possible effects of the crude extracts of L. smirnowii (CELS) and the monodesmoside's purified extract (MPE) of L. smirnowii in the carrageenan- and histamine-induced acute inflammation models in rats. The experiment revealed that CELS and MPE have anti-inflammatory effects, dose dependently in carrageenan-induced acute inflammation. On the other hand, their proinflammatory effects were surprisingly observed, especially in low doses, in the histamine-induced acute inflammation model. Summarizing these data, we may state that CELS and MPE exert their anti-inflammatory effects via non-histaminergic pathways. © 2005 Elsevier GmbH. All rights reserved.en_US
dc.identifier.doi10.1016/j.phymed.2005.09.011
dc.identifier.endpage731en_US
dc.identifier.issn0944-7113
dc.identifier.pmid17085296
dc.identifier.scopus2-s2.0-33751067242
dc.identifier.scopusqualityQ1
dc.identifier.startpage728en_US
dc.identifier.urihttps://doi.org/10.1016/j.phymed.2005.09.011
dc.identifier.volume13en_US
dc.identifier.wosWOS:000242980800018
dc.identifier.wosqualityQ1
dc.language.isoenen_US
dc.publisherElsevier GmbH, Urban & Fischer Verlagen_US
dc.relation.ispartofPhytomedicineen_US
dc.relation.journalPhytomedicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBerberidaceaeen_US
dc.subjectCarrageenanen_US
dc.subjectHistamineen_US
dc.subjectInflammationen_US
dc.subjectLeontice smirnowiien_US
dc.subjectMonodesmosidesen_US
dc.titleEffects of Leontice Smirnowii Tuber Monodesmosides and Crude Extract in Carrageenan- and Histamine-Induced Acute Inflammation Model of Ratsen_US
dc.typeArticleen_US
dspace.entity.typePublication

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