The Comparison of Imipramine and Desmopressin (DDAVP) Long-Term Therapy Results in Adult Enuresis Nocturna

Abstract

The long-term therapy results of Imipramine and Desmopressin were compared in 35 adult patients with monosymptomatic enuresis nocturna. Randomly selected 17 patients were treated with 1 mg/kg oral Imipramine and 18 with 20 μg intranasal Desmopressin nightly for three months. Dose titration was done for Desmopressin monthly. Complete improvement rates in the Desmopressin group were 55%, 61% and 72% after the first, the second and the third months respectively, whereas in the Imipramine group these were found 23%, 40% and 47%, respectively. The difference between the improvement rates of two groups were not statistically significant (p > 0.05). Three months after the end of therapy, complete improvement rates were 30% and 28% for Desmopressin and Imipramine respectively. Relapse rates were 61% in the Desmopressin group and 30% in the Imipramine group (p < 0.05). No serious side effects were observed in both groups. No difference have found between the efficacies of Imipramine and Desmopressin in long-term therapy of adult enuresis nocturna.