Chromosomal Abnormalities in Couples with Recurrent Pregnancy Loss

Abstract

Recurrent miscarriages affect approximately 5% of couples trying to establish a family. In this study we have investigated the chromosomal constitution of couples of with recurrent pregnancy losses in order to determine chromosomal anomaly frequencies. Samples of venous blood were obtained from 318 couples with recurrent miscarriages. Karyotyping was performed on peripheral blood lymphocytes (PBL) according to standard methods and 20 G-banded metaphases were analyzed in each case. We found abnormal chromosomes in 2.2% of patients. We conclude that patients with recurrent miscarriages should be routinely karyotyped.