Publication:
Oncogenic and Tumor Suppressor Function of Meis and Associated Factors

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dc.authorscopusid57220997415
dc.authorscopusid57211607968
dc.authorscopusid37026278700
dc.authorwosidKocabas, Fatih/B-2975-2012
dc.authorwosidKaradag Alpaslan, Medine/Y-7512-2018
dc.authorwosidKocabas, Fatih/Aam-6391-2021
dc.authorwosidKaradağ Alpaslan, Medine/Y-7512-2018
dc.contributor.authorGirgin, Birkan
dc.contributor.authorKaradag-Alpaslan, Medine
dc.contributor.authorKocabas, Fatih
dc.contributor.authorIDKocabas, Fatih/0000-0001-8096-6056
dc.contributor.authorIDKaradag Alpaslan, Medine/0000-0002-9115-275X
dc.contributor.authorIDGirgin, Birkan/0000-0002-4413-9739
dc.date.accessioned2025-12-11T01:26:57Z
dc.date.issued2020
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Girgin, Birkan; Kocabas, Fatih] Yeditepe Univ, Fac Engn, Dept Genet & Bioengn, Regenerat Biol Res Lab, Istanbul, Turkey; [Girgin, Birkan; Kocabas, Fatih] Yeditepe Univ, Grad Sch Nat & Appl Sci, Istanbul, Turkey; [Girgin, Birkan; Kocabas, Fatih] Meinox Pharma Technol, Istanbul, Turkey; [Karadag-Alpaslan, Medine] Ondokuz Mayis Univ, Fac Med, Dept Med Genet, Samsun, Turkeyen_US
dc.descriptionKocabas, Fatih/0000-0001-8096-6056; Karadag Alpaslan, Medine/0000-0002-9115-275X; Girgin, Birkan/0000-0002-4413-9739;en_US
dc.description.abstractMEIS proteins are historically associated with tumorigenesis, metastasis, and invasion in cancer. MEIS and associated PBX-HOX proteins may act as tumor suppressors or oncogenes in different cellular settings. Their expressions tend to be misregulated in various cancers. Bioinformatic analyses have suggested their upregulation in leukemia/lymphoma, thymoma, pancreas, glioma, and glioblastoma, and downregulation in cervical, uterine, rectum, and colon cancers. However, every cancer type includes, at least, a subtype with high MEIS expression. In addition, studies have highlighted that MEIS proteins and associated factors may function as diagnostic or therapeutic biomarkers for various diseases. Herein, MEIS proteins and associated factors in tumorigenesis are discussed with recent discoveries in addition to how they could be modulated by noncoding RNAs or newly developed small-molecule MEIS inhibitors.en_US
dc.description.sponsorshipGilead Sciences International Hematology & Oncology program; ERA-Net CVD program [118S929]en_US
dc.description.sponsorshipFK was supported by funds provided by the Gilead Sciences International Hematology & Oncology program, Gilead ile Hayat Bulan Fikirler, and ERA-Net CVD program (118S929). We apologize to those whose work could not be discussed or cited in this review due to size limitations.en_US
dc.description.woscitationindexScience Citation Index Expanded
dc.identifier.doi10.3906/biy-2006-25
dc.identifier.endpage355en_US
dc.identifier.issn1300-0152
dc.identifier.issn1303-6092
dc.identifier.issue6en_US
dc.identifier.pmid33402862
dc.identifier.scopus2-s2.0-85097974955
dc.identifier.scopusqualityQ3
dc.identifier.startpage328en_US
dc.identifier.trdizinid438501
dc.identifier.urihttps://doi.org/10.3906/biy-2006-25
dc.identifier.urihttps://search.trdizin.gov.tr/en/yayin/detay/438501/oncogenic-and-tumor-suppressor-function-of-meis-and-associated-factors
dc.identifier.urihttps://hdl.handle.net/20.500.12712/43795
dc.identifier.volume44en_US
dc.identifier.wosWOS:000601387600001
dc.identifier.wosqualityQ3
dc.language.isoenen_US
dc.publisherTÜBİTAK Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal of Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMeisen_US
dc.subjectCanceren_US
dc.subjectSmall Moleculesen_US
dc.subjectMeis Inhibitorsen_US
dc.titleOncogenic and Tumor Suppressor Function of Meis and Associated Factorsen_US
dc.typeArticleen_US
dspace.entity.typePublication

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