Protective Effects of Proanthocyanidin on Allograft Renal Oxidative Stress: An Experimental Study

Abstract

Kidney transplantation is the first treatment option for end stage of the kidney disease. Proanthocyanidins (PC) have been reported to possess a wide range of biologic properties against oxidative stress. In this study, we aimed to investigate the effects of PC extract against ischemia related oxidative stress and injury. Rats were divided into four groups in our study. The first group served as a control (CG) was observed and fed with commercial diet for three days. Third day of observation after. The second group was proanthocyanidin given group (PCG). Proanthocyanid was added to commercial diet. The third group was ischemia group (IG). The Kidneys were preserved in UW solution around 4°C for 24 h after nephrectomy without given PC. The fourth group of animals was the treatment group (TG). PC added for feeding for three days before nephrectomy. Kidney preserved like third group. The result of malondialdehyde (MDA) levels were higher and superoxide dismutase (SOD), glutation peroxidase (GSH-Px), catalase (CAT) activities were lower in IG compared with CG (P<0.05). MDA levels were almost the same in TG and CG. Other parameters were higher in CG compared with IG (P<0.05). The administration of PC may be useful to improve ischemia related oxidative stress and injury.