Publication:
Association of Matrix Metalloproteinase-3 (MMP-3) Gene Methylation Status with the Risk of Developing Achilles Tendonitis: A Preliminary Study

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dc.authorscopusid6504531151
dc.authorscopusid58297011000
dc.authorscopusid57204814111
dc.authorscopusid23471430800
dc.contributor.authorTural, E.
dc.contributor.authorBetul Celik, Z.
dc.contributor.authorTekcan, E.
dc.contributor.authorTural, S.
dc.date.accessioned2025-12-11T01:52:07Z
dc.date.issued2023
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Tural] Ercan, Department of Physiotherapy and Rehabilitation, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Betul Celik] Z., Department of Medical Biology, Samsun University, Samsun, Samsun, Turkey; [Tekcan] Esra, Department of Medical Biology, Ondokuz Mayis University, Medical School, Samsun, Turkey; [Tural] Şengül, Department of Medical Biology, Ondokuz Mayis University, Medical School, Samsun, Turkeyen_US
dc.description.abstractIntroduction: In this study, we aimed to examine the relationship between the MMP-3 gene promoter methylation status and the risk of developing achilles tendinitis in endurance athletes. Materials and Methods: A total of 20 endurance athletes with achille tendonitis and 20 sedantary controls were involved in the study. DNA isolation and bisulfite modification were performed from peripheral blood samples of all volunteers. Using methylation-specific primers designed for MMP-3 gene promoters, methylation profiles were analyzed by the methylation specific polymerase chain reaction method. Results: In the MMP-3 gene promoter methylation analysis, the methylation frequency was found to be 75% in athletes with Achilles tendinitis, while it was found to be 100% in the control group. MMP-3 promoter region methylation status in the patient group was found to be hypomethylated compared to the control group. Discussion and Conclusion: The hypomethylated status of the MMP-3 gene promoter may have a role in developing achilles tendonitis in athletes. Furher and larges studies are needed to confirm our results. © 2023, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.en_US
dc.identifier.doi10.5505/vtd.2023.88864
dc.identifier.endpage26en_US
dc.identifier.issn1300-2694
dc.identifier.issn2587-0351
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-105003305036
dc.identifier.startpage22en_US
dc.identifier.trdizinid1165805
dc.identifier.urihttps://doi.org/10.5505/vtd.2023.88864
dc.identifier.urihttps://search.trdizin.gov.tr/en/yayin/detay/1165805/association-of-matrix-metalloproteinase-3-mmp-3-gene-methylation-status-with-the-risk-of-developing-achilles-tendonitis-a-preliminary-study
dc.identifier.urihttps://hdl.handle.net/20.500.12712/47157
dc.identifier.volume30en_US
dc.language.isoenen_US
dc.publisherYuzuncu Yil Universitesi Tip Fakultesien_US
dc.relation.ispartofVan Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEpigenomicsen_US
dc.subjectMethylationen_US
dc.subjectTendonopathyen_US
dc.titleAssociation of Matrix Metalloproteinase-3 (MMP-3) Gene Methylation Status with the Risk of Developing Achilles Tendonitis: A Preliminary Studyen_US
dc.title.alternativeMatriks Metalloproteinaz-3 (MMP-3) Geni Metilasyon Durumunun Aşil Tendiniti Gelişimi Riski İle İlişkisi: Bir Ön Çalışmaen_US
dc.typeArticleen_US
dspace.entity.typePublication

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