Publication:
Evaluation of CYP17A1 and LEP Gene Polymorphisms in Breast Cancer

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dc.authorscopusid24781203900
dc.authorscopusid6603455076
dc.authorscopusid9732974500
dc.authorscopusid6603462088
dc.authorscopusid23471430800
dc.authorscopusid6603025806
dc.contributor.authorKarakuş, N.
dc.contributor.authorKara, N.
dc.contributor.authorUlusoy, A.N.
dc.contributor.authorÖzaslan, C.
dc.contributor.authorTural, S.
dc.contributor.authorOkan, I.
dc.date.accessioned2020-06-21T13:45:33Z
dc.date.available2020-06-21T13:45:33Z
dc.date.issued2015
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Karakuş] Nevin, Department of Medical Biology, Tokat Gaziosmanpaşa Üniversitesi, Tokat, Turkey; [Kara] Nurten, Department of Medical Biology, Ondokuz Mayis University, Medical School, Samsun, Turkey; [Ulusoy] Ali Naki, Department of General Surgery, Ondokuz Mayis University, Medical School, Samsun, Turkey; [Özaslan] Cihangir, Department of General Surgery, Ankara Oncology Education and Research Hospital, Ankara, Turkey; [Tural] Şengül, Department of Medical Biology, Ondokuz Mayis University, Medical School, Samsun, Turkey; [Okan] Ismail, Department of General Surgery, Tokat Gaziosmanpaşa Üniversitesi, Tokat, Turkeyen_US
dc.description.abstractPolymorphisms of estrogen synthesis-and adiposity-related genes can contribute to the development of breast cancer. The purpose of the current study was to analyze the association between CYP17A1 T27C (rs743572) and LEP-2548G>A (rs7799039) gene polymorphisms and breast cancer. Material and Methods: 199 breast cancer patients and 197 healthy controls were included in the study. The CYP17A1 and LEP gene polymorphisms were determined using polymerase chain reaction-based restriction fragment length polymorphism analysis. Results: No statistically significant association was found between these polymorphisms and breast cancer risk among a Turkish population. However, stratified analysis of these polymorphisms in relation to different clinicopathological characteristics of breast cancer revealed an association between breast cancer diagnosis and the CYP17A1 T27C polymorphism (p = 0.024). Conclusion: Our study suggests no strong association between the CYP17A1 T27C and LEP-2548G>A polymorphisms and the incidence of breast cancer in Turkish women. The potential association between CYP17A1 T27C and the type of breast cancer deserves further consideration. © 2015 S. Karger GmbH, Freiburg.en_US
dc.identifier.doi10.1159/000438940
dc.identifier.endpage422en_US
dc.identifier.issn2296-5270
dc.identifier.issn2296-5262
dc.identifier.issue9en_US
dc.identifier.pmid26407154
dc.identifier.scopus2-s2.0-84947917203
dc.identifier.scopusqualityQ3
dc.identifier.startpage418en_US
dc.identifier.urihttps://doi.org/10.1159/000438940
dc.identifier.volume38en_US
dc.identifier.wosWOS:000361090300002
dc.identifier.wosqualityQ4
dc.language.isoenen_US
dc.publisherS. Karger AGen_US
dc.relation.ispartofOncology Research and Treatmenten_US
dc.relation.journalOncology Research and Treatmenten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBreast Canceren_US
dc.subjectCYP17A1en_US
dc.subjectGenetic Susceptibilityen_US
dc.subjectLeptinen_US
dc.subjectPolymorphismen_US
dc.titleEvaluation of CYP17A1 and LEP Gene Polymorphisms in Breast Canceren_US
dc.typeArticleen_US
dspace.entity.typePublication

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