Publication:
Autoantibodies Against Type I IFNs in Patients With Life-Threatening COVID-19

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dc.authorscopusid57219618314
dc.authorscopusid55200672600
dc.authorscopusid57201744949
dc.authorscopusid35345365800
dc.authorscopusid49961637600
dc.authorscopusid56046945000
dc.authorscopusid57220806366
dc.contributor.authorBastard, P.
dc.contributor.authorRosen, L.B.
dc.contributor.authorZhang, Q.
dc.contributor.authorMichailidis, E.
dc.contributor.authorHoffmann, H.-H.
dc.contributor.authorZhang, Y.
dc.contributor.authorDorgham, K.
dc.date.accessioned2025-12-11T00:27:04Z
dc.date.issued2020
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Bastard] Paul, Laboratory of Human Genetics of Infectious Diseases, Hôpital Necker Enfants Malades, Paris, France, Université Paris Cité, Paris, Ile-de-France, France, St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller University, New York, NY, United States; [Rosen] Lindsey B., Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD, United States; [Zhang] Qian, St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller University, New York, NY, United States; [Michailidis] Eleftherios, Laboratory of Virology and Infectious Disease, Rockefeller University, New York, NY, United States; [Hoffmann] Hans Heinrich, Laboratory of Virology and Infectious Disease, Rockefeller University, New York, NY, United States; [Zhang] Yu, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD, United States; [Dorgham] Karim, Sorbonne Université, Paris, Ile-de-France, France; [Philippot] Quentin, Laboratory of Human Genetics of Infectious Diseases, Hôpital Necker Enfants Malades, Paris, France, Université Paris Cité, Paris, Ile-de-France, France; [Rosain] Jérémie, Laboratory of Human Genetics of Infectious Diseases, Hôpital Necker Enfants Malades, Paris, France, Université Paris Cité, Paris, Ile-de-France, France; [Béziat] Vivien, Laboratory of Human Genetics of Infectious Diseases, Hôpital Necker Enfants Malades, Paris, France, Université Paris Cité, Paris, Ile-de-France, France, St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller University, New York, NY, United States; [Manry] Jeremy, Laboratory of Human Genetics of Infectious Diseases, Hôpital Necker Enfants Malades, Paris, France, Université Paris Cité, Paris, Ile-de-France, France; [Shaw] Elana R., Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD, United States; [Haljasmägi] Liis, Institute of Biomedicine and Translational Medicine, Tartu Ülikool, Tartu, Tartumaa, Estonia; [Peterson] Pärt, Institute of Biomedicine and Translational Medicine, Tartu Ülikool, Tartu, Tartumaa, Estonia; [Lorenzo] Lazaro, Laboratory of Human Genetics of Infectious Diseases, Hôpital Necker Enfants Malades, Paris, France, Université Paris Cité, Paris, Ile-de-France, France; [Bizien] Lucy, Laboratory of Human Genetics of Infectious Diseases, Hôpital Necker Enfants Malades, Paris, France, Université Paris Cité, Paris, Ile-de-France, France; [Trouillet-Assant] Sophie, Centre Hospitalier Lyon-Sud, Lyon, France, École Normale Supérieure de Lyon, Lyon, Auvergne-Rhone-Alpes, France; [Dobbs] Kerry, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD, United States; [de Jesus] Adriana Almeida, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD, United States; [Belot] Alexandre, École Normale Supérieure de Lyon, Lyon, Auvergne-Rhone-Alpes, France, National Referee Centre for Rheumatic, Lyon, France, CHU de Lyon, Lyon, Auvergne-Rhone-Alpes, France; [Kallaste] Anne, Internal Medicine Clinic, Tartu Ülikooli Kliinikum, Tartu, Tartumaa, Estonia; [Catherinot] Émilie, Pneumology Department, Foch Hospital, Suresne, France; [Tandjaoui-Lambiotte] Yacine, Hopital Avicenne, Bobigny, France; [Le Pen] Jérémie, Laboratory of Virology and Infectious Disease, Rockefeller University, New York, NY, United States; [Kerner] Gaspard, Laboratory of Human Genetics of Infectious Diseases, Hôpital Necker Enfants Malades, Paris, France, Université Paris Cité, Paris, Ile-de-France, France; [Bigio] Benedetta, St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller University, New York, NY, United States; [Seeleuthner] Yoann, Laboratory of Human Genetics of Infectious Diseases, Hôpital Necker Enfants Malades, Paris, France, Université Paris Cité, Paris, Ile-de-France, France; [Yang] Rui, St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller University, New York, NY, United States; [Bolze] Alexandre, Helix, San Mateo, CA, United States; [Spaan] András N., University Medical Center Utrecht, Utrecht, Netherlands; [Delmonte] Ottavia Maria, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD, United States; [Abers] Michael S., Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD, United States; [Aïuti] Alessandro, Università Vita-Salute San Raffaele, Milan, MI, Italy; [Casari] Giorgio, Università Vita-Salute San Raffaele, Milan, MI, Italy, Medical Genetics, IRCCS Ospedale San Raffaele, Milan, MI, Italy; [Lampasona] Vito, Università Vita-Salute San Raffaele, Milan, MI, Italy; [Piemonti] Lorenzo, Università Vita-Salute San Raffaele, Milan, MI, Italy; [Ciceri] Fabio, Università Vita-Salute San Raffaele, Milan, MI, Italy; [Bilgüvar] Kaya, Department of Genetics, Yale School of Medicine, New Haven, CT, United States; [Lifton] Richard P., Department of Genetics, Yale School of Medicine, New Haven, CT, United States, Yale School of Medicine, New Haven, CT, United States, Laboratory of Human Genetics and Genomics, Rockefeller University, New York, NY, United States; [Vasse] Marc, Service de Biologie Clinique, Hopital Foch, Suresnes, France, Consorcio Hospital, General Universitario, Valencia, Spain; [Smadja] David M., biosurgical research laboratory (Carpentier Foundation), Innovations Thérapeutiques en Hémostase, Paris, Ile-de-France, France; [Migaud] Mélanie, Laboratory of Human Genetics of Infectious Diseases, Hôpital Necker Enfants Malades, Paris, France, Université Paris Cité, Paris, Ile-de-France, France; [Hadjadj] Jérome, Department of Internal Medicine, Hopital Cochin AP-HP, Paris, Ile-de-France, France; [Terrier] Benjamin, Department of Internal Medicine, Université Paris Cité, Paris, Ile-de-France, France; [Duffy] Darragh, Translational Immunology Lab, Institut Pasteur, Paris, Paris, Ile-de-France, France, Institut Pasteur, Paris, Paris, Ile-de-France, France; [Quintana-Murci] Lluís, Collège de France, Paris, Ile-de-France, France; [van de Beek] Diederik V.D., Department of Neurology, Universiteit van Amsterdam, Amsterdam, Noord-Holland, Netherlands; [Roussel] Lucie, Department of Medicine, Centre Universitaire de Santé McGill, Montreal, QC, Canada, Infectious Disease Susceptibility Program, L'Institut de Recherche du Centre Universitaire de Santé McGill, Montreal, QC, Canada; [Vinh] Donald C., Department of Medicine, Centre Universitaire de Santé McGill, Montreal, QC, Canada, Infectious Disease Susceptibility Program, L'Institut de Recherche du Centre Universitaire de Santé McGill, Montreal, QC, Canada, Centre Universitaire de Santé McGill, Montreal, QC, Canada; [Tangye] Stuart G., Garvan Institute of Medical Research, Sydney, NSW, Australia, UNSW Medicine, Kensington, NSW, Australia, Garvan Institute of Medical Research, Sydney, NSW, Australia; [Haerynck] Filomeen, Department of Paediatric Immunology and Pulmonology, Universitair Ziekenhuis Gent, Ghent, VOV, Belgium; [Dalmau] David, Fundació Docència I Recerca Mutua Terrassa, Barcelona, Spain; [Martínez-Picado] Javier, IrsiCaixa AIDS Research Institute, Fundació Institut dInvestigació en Ciències de la Salut Germans Trias i Pujol, Badalona, Spain, Infectious Diseases and Immunity, Universitat de Vic - Universitat Central de Catalunya (UVic-UCC), Vic, Barcelona, Spain, Institució Catalana de Recerca i Estudis Avançats, Barcelona, Barcelona, Spain; [Brodin] Petter, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Stockholms, Sweden, Pediatric Rheumatology, Karolinska Universitetssjukhuset, Stockholm, Stockholms, Sweden, Karolinska Institutet, Stockholm, Stockholms, Sweden; [Nussenzweig] Michel C., Laboratory of Molecular Immunology, Rockefeller University, New York, NY, United States, Howard Hughes Medical Institute, Chevy Chase, MD, United States; [Boisson-Dupuis] Stéphanie, Laboratory of Human Genetics of Infectious Diseases, Hôpital Necker Enfants Malades, Paris, France, Université Paris Cité, Paris, Ile-de-France, France, St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller University, New York, NY, United States; [Rodríguez-Gallego] Carlos, Hospital de Gran Canaria Dr. Negrin, Las Palmas de Gran Canaria, Las Palmas, Spain; [Vogt] Guillaume, Neglected Human Genetics Laboratory, Université Paris Cité, Paris, Ile-de-France, France; [Mogensen] Trine Hyrup, Department of Infectious Diseases, Aarhus Universitetshospital, Aarhus, Midtjylland, Denmark, Department of Biomedicine, Aarhus Universitet, Aarhus, Midtjylland, Denmark, Aarhus Universitet, Aarhus, Midtjylland, Denmark; [Oler] Andrew J., Bioinformatics and Computational Biosciences Branch, National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD, United States; [Gu] Jingwen, Bioinformatics and Computational Biosciences Branch, National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD, United States; [Burbelo] Peter Denis, Division of Intramural Research, National Institute of Dental and Craniofacial Research (NIDCR), Bethesda, MD, United States; [Cohen] Jeffrey I., Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD, United States; [Biondi] Andrea, Department of Pediatrics, Università degli Studi di Milano-Bicocca, Milan, MI, Italy; [Bettini] Laura Rachele, Department of Pediatrics, Università degli Studi di Milano-Bicocca, Milan, MI, Italy; [D’Angiò] Mariella, Department of Pediatrics, Università degli Studi di Milano-Bicocca, Milan, MI, Italy; [Bonfanti] Paolo, Department of Infectious Diseases, Università degli Studi di Milano-Bicocca, Milan, MI, Italy; [Rossignol] Patrick, Clinical Investigation Centre, Université de Lorraine, Nancy, Grand Est, France; [Mayaux] Julien, Hôpital Universitaire Pitié Salpêtrière, Paris, Ile-de-France, France; [Rieux-Laucat] Frédéric, Laboratory of Immunogenetics of Pediatric Autoimmune Diseases, Université Paris Cité, Paris, Ile-de-France, France; [Husebye] Eystein Sverre, Department of Clinical Science and K.G. Jebsen Center for Autoimmune Disorders, Universitetet i Bergen, Bergen, Hordaland, Norway, Department of Medicine, Haukeland Universitetssjukehus, Bergen, Hordaland, Norway, Department of Medicine Solna, Karolinska Institutet, Stockholm, Stockholms, Sweden; [Fusco] Francesca, Human Molecular Genetics Laboratory, Institute of Genetics and Biophysics Adriano Buzzati Traverso, Naples, NA, Italy; [Ursini] Matilde Valeria, Institute of Genetics and Biophysics Adriano Buzzati Traverso, Naples, NA, Italy; [Imberti] Luisa, Diagnostic Department, Spedali Civili Di Brescia, Brescia, BS, Italy; [Sottini] Alessandra, Diagnostic Department, Spedali Civili Di Brescia, Brescia, BS, Italy; [Paghera] Simone, Diagnostic Department, Spedali Civili Di Brescia, Brescia, BS, Italy; [Quiròs-Roldan] Eugenia, Department of Infectious and Tropical Diseases, Università degli Studi di Brescia, Brescia, BS, Italy; [Rossi] Camillo, Direzione Sanitaria, Spedali Civili Di Brescia, Brescia, BS, Italy; [Castagnoli] Riccardo, Department of Pediatrics, Università degli Studi di Pavia, Pavia, PV, Italy; [Montagna] Daniela, Laboratory of Immunology and Transplantation, Fondazione IRCCS Policlinico San Matteo, Pavia, PV, Italy, Surgical, Università degli Studi di Pavia, Pavia, PV, Italy; [Licari] Amelia, Department of Pediatrics, Università degli Studi di Pavia, Pavia, PV, Italy; [Marseglia] Gian Luigi, Department of Pediatrics, Università degli Studi di Pavia, Pavia, PV, Italy; [Duval] Xavier, Inserm, Paris, Ile-de-France, France, Hôpital Bichat-Claude-Bernard AP-HP, Paris, France, Université Paris Cité, Paris, Ile-de-France, France, Université Paris Cité, Paris, Ile-de-France, France, Infectious and Tropical Diseases Department, Hôpital Bichat-Claude-Bernard AP-HP, Paris, France; [Ghosn] Jade, Hôpital Bichat-Claude-Bernard AP-HP, Paris, France; [Tsang] John S., Center for Human Immunology, National Institutes of Health (NIH), Bethesda, MD, United States, Multiscale Systems Biology Section, National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD, United States; [Goldbach-Mansky] Raphaela T., Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD, United States; [Kisand] Kai E., Institute of Biomedicine and Translational Medicine, Tartu Ülikool, Tartu, Tartumaa, Estonia; [Lionakis] Michail S., Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD, United States; [Puel] Anne, Laboratory of Human Genetics of Infectious Diseases, Hôpital Necker Enfants Malades, Paris, France, Université Paris Cité, Paris, Ile-de-France, France, St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller University, New York, NY, United States; [Zhang] Shenying, Laboratory of Human Genetics of Infectious Diseases, Hôpital Necker Enfants Malades, Paris, France, Université Paris Cité, Paris, Ile-de-France, France, St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller University, New York, NY, United States; [Holland] Steven M., Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD, United States; [Gorochov] Guy, Sorbonne Université, Paris, Ile-de-France, France, Department of Immunology, Hôpital Universitaire Pitié Salpêtrière, Paris, Ile-de-France, France; [Jouanguy] Emmanuelle, Laboratory of Human Genetics of Infectious Diseases, Hôpital Necker Enfants Malades, Paris, France, Université Paris Cité, Paris, Ile-de-France, France, St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller University, New York, NY, United States; [Rice] Charles M., Laboratory of Virology and Infectious Disease, Rockefeller University, New York, NY, United States; [Cobat] Aurélie, Laboratory of Human Genetics of Infectious Diseases, Hôpital Necker Enfants Malades, Paris, France, Université Paris Cité, Paris, Ile-de-France, France, St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller University, New York, NY, United States; [Notarangelo] Luigi Daniele, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD, United States; [Abel] Laurent, Laboratory of Human Genetics of Infectious Diseases, Hôpital Necker Enfants Malades, Paris, France, Université Paris Cité, Paris, Ile-de-France, France, St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller University, New York, NY, United States; [Su] Helen C., Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD, United States; [Casanova] Jean Laurent, Laboratory of Human Genetics of Infectious Diseases, Hôpital Necker Enfants Malades, Paris, France, Université Paris Cité, Paris, Ile-de-France, France, St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller University, New York, NY, United States, Howard Hughes Medical Institute, Chevy Chase, MD, United States, Pediatric Hematology-Immunology Unit, Hôpital Necker Enfants Malades, Paris, France; [Arias] Andrés Augusto, Group of Primary Immunodeficiencies, Universidad de Antioquia, Medellin, Antioquia, Colombia; [Boisson] Bertrand, St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller University, New York, NY, United States, Laboratory of Human Genetics of Infectious Diseases, Hôpital Necker Enfants Malades, Paris, France; [Boucherit] Soraya, Laboratory of Human Genetics of Infectious Diseases, Hôpital Necker Enfants Malades, Paris, France; [Bustamante] Jacinta C., St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller University, New York, NY, United States, Laboratory of Human Genetics of Infectious Diseases, Hôpital Necker Enfants Malades, Paris, France; [Chbihi] Marwa, Laboratory of Human Genetics of Infectious Diseases, Hôpital Necker Enfants Malades, Paris, France; [Chen] Jie, St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller University, New York, NY, United States; [Chrabieh] Maya, Laboratory of Human Genetics of Infectious Diseases, Hôpital Necker Enfants Malades, Paris, France; [Kochetkov] Tatiana, St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller University, New York, NY, United States; [Le Voyer] Tom, Laboratory of Human Genetics of Infectious Diseases, Hôpital Necker Enfants Malades, Paris, France; [Liu] Dana, St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller University, New York, NY, United States; [Nemirovskaya] Yelena, St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller University, New York, NY, United States; [Ogishi] Masato, St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller University, New York, NY, United States; [Papandrea] Dominick, St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller University, New York, NY, United States; [Patissier] Cécile, Laboratory of Human Genetics of Infectious Diseases, Hôpital Necker Enfants Malades, Paris, France; [Rapaport] Franck T., St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller University, New York, NY, United States; [Roynard] Manon, Laboratory of Human Genetics of Infectious Diseases, Hôpital Necker Enfants Malades, Paris, France; [Vladikine] Natasha, Laboratory of Human Genetics of Infectious Diseases, Hôpital Necker Enfants Malades, Paris, France; [Woollett] Mark, St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller University, New York, NY, United States; [Zhang] Peng, St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller University, New York, NY, United States; [Kashyap] Anuj K., Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD, United States; [Ding] Li, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD, United States; [Bosticardo] Marita, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD, United States; [Wang] Qinlu, Bioinformatics and Computational Biosciences Branch, National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD, United States; [Ochoa] Sebastian, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD, United States; [Liu] Hui, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD, United States; [Chauvin] Samuel D., Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD, United States; [Stack] Michael A., Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD, United States; [Koroleva] Galina I., National Institutes of Health (NIH), Bethesda, MD, United States; [Bansal] Neha M., Multiscale Systems Biology Section, National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD, United States; [Dalgard] Clifton L., Uniformed Services University of the Health Sciences, Bethesda, MD, United States, Department of Anatomy, Uniformed Services University of the Health Sciences, Bethesda, MD, United States; [Snow] Andrew L., Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States; [Abad] Jorge L., Hospital Universitari Germans Trias i Pujol, Badalona, Spain; [Aguilera-Albesa] Sergio, Navarra Health Service Hospital, Pamplona, Spain; [Akcan] Ozge Metin, Meram Medical Faculty, Necmettin Erbakan Üniversitesi, Meram, Konya, Turkey; [Alavi Darazam] Ilad, Department of Infectious Diseases, Loghman Hakim Educational Hospital, Tehran, Tehran, Iran; [Aldave-Becerra] Juan Carlos, Hospital Nacional Edgardo Rebagliati Martins, EsSalud, Lima, Lima, Peru; [Ramos] Miquel Alfonso, Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, Catalonia, Spain; [Nadji] Seyed Alireza, Virology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Tehran, Iran; [Alkan] Gülsüm, Department of Pediatric Infectious Diseases, Selçuk Tip Fakültesi, Konya, Turkey; [Allardet-Servent] Jérôme, Intensive Care Unit, Hôpital Européen, Marseille, France; [Allende] Luís Miguel, Department of Immunology, Hospital Universitario 12 de Octubre, Madrid, Madrid, Spain; [Alsina] Laia, Hospital Sant Joan de Déu Barcelona, Esplugues de Llobregat, Barcelona, Spain; [Alyanakian] Marie Alexandra, Department of Immunology, Hôpital Necker Enfants Malades, Paris, France; [Amador-Borrero] Blanca, Department of Internal Medicine, Université Paris Cité, Paris, Ile-de-France, France; [Amoura] Zahir, Department of Internal Medicine, Hôpital Universitaire Pitié Salpêtrière, Paris, Ile-de-France, France; [Antoli] Arnau, Hospital Universitari de Bellvitge, Barcelona, Barcelona, Spain; [Arslan] Sevket, Meram Medical Faculty, Necmettin Erbakan Üniversitesi, Meram, Konya, Turkey; [Assant] Sophie, Joint Research Unit, Centre Hospitalier Lyon-Sud, Lyon, France; [Auguet] T., Hospital Universitario Joan XXIII de Tarragona, Tarragona, Tarragones, Spain; [Azot] Axelle, Private Practice, Paris, France; [Bajolle] Fanny, Hôpital Necker Enfants Malades, Paris, France; [Baldolli] Aurélie, Department of Infectious Diseases, CHU de Caen Normandie, Caen, Normandie, France; [Ballester] Maite,; [Feldman] Hagit Baris, Institute for Genetics, Tel Aviv University, Tel Aviv-Yafo, Tel Aviv District, Israel; [Barŕou] Benoît M., Department of Urology, Sorbonne Université, Paris, Ile-de-France, France; [Beurton] Alexandra, Service de Médecine Intensive-Réanimation et Pneumologie, Hôpital Universitaire Pitié Salpêtrière, Paris, Ile-de-France, France; [Bilbao] Agurtzane, Osakidetza, Cruces University Hospital, Baracaldo, Biscay, Spain; [Blanchard-Rohner] Géraldine, Paediatric Immunology and Vaccinology Unit, Hôpitaux Universitaires de Genève, Geneva, GE, Switzerland; [Blanco] Ignacio, Hospital Universitari Germans Trias i Pujol, Badalona, Spain; [Blandinières] Adeline, Department of Hematology, Hôpital Européen Georges-Pompidou, Paris, Ile-de-France, France; [Blázquez-Gamero] Daniel, Pediatric Infectious Diseases Unit, Hospital Universitario 12 de Octubre, Madrid, Madrid, Spain; [Bloomfield] Markéta, Department of Pediatrics, Fakultní Nemocnice v Motole, Prague, Czech Republic; [Bolívar-Prados] Mireia, Hospital de Mataro, Barcelona, Barcelona, Spain; [Borie] Raphaël, Service of Pneumology, Hôpital Bichat-Claude-Bernard AP-HP, Paris, France; [Bousfiha] Ahmed Aziz, Department of Pediatric Infectious Diseases, CHU Averroes, Casablanca, Grand Casablanca, Morocco; [Bouvattier] Claire E., Endocrinology Unit, APHP Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicetre, France; [Boyarchuk] Oksana R., Department of Children's Diseases and Pediatric Surgery, I. Horbachevsky Ternopil National Medical University, Ternopil, Ternopil Oblast, Ukraine; [Bueno] Maria Rita Passos, Human Genome and Stem Cell Research Center, Universidade de São Paulo, Sao Paulo, SP, Brazil; [Agra] Juan José Caceres, Complejo Hospitalario Universitario Insular Materno-Infantil, Las Palmas de Gran Canaria, Las Palmas, Spain; [Calimli] Semra, Department of Anesthesiology, Konya State Hospital, Konya, Konya, Turkey; [Capra] Ruggero, MS Center, Spedali Civili Di Brescia, Brescia, BS, Italy; [Carrabba] Maria Domenica, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, MI, Italy; [Casasnovas] C., Hospital Universitari de Bellvitge, Barcelona, Barcelona, Spain; [Caséris] Marion, Hôpital Robert-Debré AP-HP, Paris, France; [Castelle] Martin, Pediatric Immuno-Hematology Unit, Hôpital Necker Enfants Malades, Paris, France; [Castelli] Francesco, Department of Infectious and Tropical Diseases, Università degli Studi di Brescia, Brescia, BS, Italy; [de Vera] Martin Castillo, Doctoral Health Care Center, Canarian Health System, Las Palmas de Gran Canaria, Spain; [de Castro] Mateus V., Human Genome and Stem Cell Research Center, Universidade de São Paulo, Sao Paulo, SP, Brazil; [Chalumeau] Martin, Hôpital Necker Enfants Malades, Paris, France; [Charbit] Bruno, Institut Pasteur, Paris, Paris, Ile-de-France, France; [Cheng] Matthew P., Centre Universitaire de Santé McGill, Montreal, QC, Canada; [Clavé] Pere, Hospital de Mataro, Barcelona, Barcelona, Spain; [Clotet] Bonaventura, IrsiCaixa AIDS Research Institute, Hospital Universitari Germans Trias i Pujol, Badalona, Spain; [Codina] Anna Esteve, Paediatric Neurology, Centro de Investigación Biomédica en Red de Enfermedades Raras, Madrid, Madrid, Spain; [Çölkesen] Fatih, Department of Internal Medicine, Necmettin Erbakan Üniversitesi, Meram, Konya, Turkey; [Colkesen] Fatma, Department of Infectious Diseases and Clinical Microbiology, Konya Meram Training and Research Hospital, Konya, Turkey; [Colobran Oriol] Roger, Hospital Universitari Vall d'Hebron, Barcelona, Barcelona, Spain; [Comarmond] Cloé, Hôpital Universitaire Pitié Salpêtrière, Paris, Ile-de-France, France; [Corsico] Angelo Guido, Division of Respiratory Diseases, Università degli Studi di Pavia, Pavia, PV, Italy; [Darley] David R., Department of Thoracic Medicine, St. Vincent's Hospital Sydney, Sydney, NSW, Australia; [Dauby] Nicolas, Université Libre de Bruxelles, Brussels, BRU, Belgium; [Dauger] Stéphane, Pediatric Intensive Care Unit, Hôpital Robert-Debré AP-HP, Paris, France; [De-Pontual] Loíc, Hopital Jean-Verdier, Bondy, France; [Dehban] Amin, Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran; [Delplancq] Geoffroy, Centre de Génétique Humaine, Centre Hospitalier Universitaire de Besançon, Besancon, Bourgogne-Franche-Comte, France; [Demoule] Alexandre, Sorbonne Université, Paris, Ile-de-France, France; [Di Sabatino] A. D., Department of Internal Medicine, Università degli Studi di Pavia, Pavia, PV, Italy; [Diehl] Jean Luc, Intensive Care Unit, Hôpital Européen Georges-Pompidou, Paris, Ile-de-France, France; [Dobbelaere] Stephanie, Department of Pneumology, AZ Delta, Roeselare, Belgium; [Durand] Sophie, Institut Jérôme Lejeune, Paris, France; [Eldars] Waleed Mahmoud, Department of Microbiology and Immunology, Faculty of Medicine, Mansoura, Dakahlia, Egypt; [Elgamal] Mohamed A., Chest Department, Faculty of Medicine, Mansoura, Dakahlia, Egypt; [Elnagdy] Marwa H., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Mansoura, Dakahlia, Egypt; [Emiroǧlu] Melike Keser, Department of Pediatric Infectious Diseases, Selçuk Tip Fakültesi, Konya, Turkey; [Erdeniz] Emine Hafize, Division of Pediatric Infectious Diseases, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Aytekin] Selma Erol, Division of Pediatric Allergy and Immunology, Necmettin Erbakan Üniversitesi, Meram, Konya, Turkey; [Euvrard] Romain, Centre Hospitalier Fleyriat, Bourg-en-Bresse, France; [Evcen] Recep, Department of Internal Medicine, Necmettin Erbakan Üniversitesi, Meram, Konya, Turkey; [Fabio] Giovanna, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, MI, Italy; [Faivre] Laurence Olivier, Centre Hospitalier Universitaire Dijon Bourgogne, Dijon, Bourgogne-Franche-Comte, France; [Falck] Antonin, Hôpital Robert-Debré AP-HP, Paris, France; [Fartoukh] Muriel Sarah, Hôpital Tenon, Paris, Ile-de-France, France; [Faure] Morgane, Sorbonne Université, Paris, Ile-de-France, France; [Arquero] Miguel Fernandez, Department of Clinical Immunology, Hospital Clínico San Carlos, Madrid, Madrid, Spain; [Flores] C. M., Genomics Division, Instituto Tecnológico y de Energías Renovables, S.A., Granadilla de Abona, Santa Cruz de Tenerife, Spain, Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Madrid, Madrid, Spain, Research Unit, Hospital Universitario Nuestra Senora de Candelaria, Santa Cruz de Tenerife, Santa Cruz de Tenerife, Spain, Universidad de la Laguna, San Cristobal de La Laguna, Santa Cruz de Tenerife, Spain, Research Unit, Hospital Universitario Nuestra Senora de Candelaria, Santa Cruz de Tenerife, Santa Cruz de Tenerife, Spain; [François] Bruno, CHU de Limoges, Limoges, France; [Fumadó] Victòria Pérez, Department of Pediatrics, Hospital Sant Joan de Déu Barcelona, Esplugues de Llobregat, Barcelona, Spain, Institut de Recerca Sant Joan de Déu, Barcelona, Catalonia, Spain, Universitat de Barcelona, Barcelona, Barcelona, Spain; [Solis] Blanca Garcia, Laboratory of Immunogenetics of Human Diseases, Instituto de Investigación Sanitaria del Hospital Universitario La Paz, Madrid, Madrid, Spain; [Gaussem] Pascale, Department of Hematology, Hôpital Européen Georges-Pompidou, Paris, Ile-de-France, France; [Gil-Herrera] Juana, Hospital General Universitario Gregorio Marañón, Madrid, Madrid, Spain; [Gilardin] Laurent, Hôpital d'Instruction des Armées Begin, Saint-Mande, France; [Alarcon] Monica Girona, Pediatric Intensive Care Unit, Hospital Sant Joan de Déu Barcelona, Esplugues de Llobregat, Barcelona, Spain; [Girona-Alarcon] Monica, Pediatric Intensive Care Unit, Hospital Sant Joan de Déu Barcelona, Esplugues de Llobregat, Barcelona, Spain; [Goffard] J. C., Department of Internal Medicine, Hôpital Erasme, Brussels, BRU, Belgium; [Gök] Funda Yarba, Department of Anesthesiology, Necmettin Erbakan Üniversitesi, Meram, Konya, Turkey; [González-Montelongo] Rafaela, Genomics Division, Instituto Tecnológico y de Energías Renovables, S.A., Granadilla de Abona, Santa Cruz de Tenerife, Spain; [Guerder] Antoine, AP-HP Assistance Publique - Hopitaux de Paris, Paris, France; [Gul] Yahya, Meram Medical Faculty, Necmettin Erbakan Üniversitesi, Meram, Konya, Turkey; [Güner] Şükrü Nail, Meram Medical Faculty, Necmettin Erbakan Üniversitesi, Meram, Konya, Turkey; [Gut] Marta, Universitat Pompeu Fabra Barcelona, Barcelona, Barcelona, Spain; [Halwani] Rabih, College of Medicine, Sharjah, United Arab Emirates, College of Medicine, Sharjah, United Arab Emirates; [Hammarström] Lennart L.G., Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Stockholms, Sweden; [Hatipoǧlu] Nevin, Pediatric Infectious Diseases Unit, University of Health Sciences, Istanbul, Turkey; [Hernandez-Brito] Elisa, Department of Immunology, Hospital de Gran Canaria Dr. Negrin, Las Palmas de Gran Canaria, Las Palmas, Spain; [Holanda] María Soledad, Intensive Care Unit, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, Spain; [Horcajada] Juan P., Hospital del Mar, Barcelona, Barcelona, Spain; [Hraiech] Sami, Medical Intensive Care Unit, AP-HM Assistance Publique - Hôpitaux de Marseille, Marseille, Provence-Alpes-Cote d'Azur, France; [Humbert] Linda, CHU Lille, Lille, Hauts-de-France, France; [Iglesias] Alejandro Daniel, Columbia University Irving Medical Center, New York, NY, United States; [Íñigo-Campos] Antonio, Genomics Division, Instituto Tecnológico y de Energías Renovables, S.A., Granadilla de Abona, Santa Cruz de Tenerife, Spain; [Jamme] Matthieu, Centre Hospitalier Intercommunal Poissy-St-Germain-en-Laye, Poissy, France; [Arranz] María Jesús, Fundació Docència I Recerca Mutua Terrassa, Barcelona, Spain; [Jordán] Iolanda, Hospital Sant Joan de Déu Barcelona, Esplugues de Llobregat, Barcelona, Spain; [Kanat] Fikret, Department of Chest Diseases, Selçuk Tip Fakültesi, Konya, Turkey; [Kapakli] Hasan, Division of Allergy and Immunology, Balıkesir Atatürk City Hospital, Balikesir, Balikesir, Turkey; [Kara] Iskender, Division of Critical Care Medicine, Selçuk Tip Fakültesi, Konya, Turkey; [Karbuz] Adem, Division of Pediatric Infectious Diseases, Prof. Dr. Cemil Tascioglu City Hospital, Istanbul, Istanbul, Turkey; [Kart-Yaşar] Kadriye, Department of Infectious Diseases and Clinical Microbiology, University of Health Sciences, Istanbul, Turkey; [Keles] Sevgi, Meram Medical Faculty, Necmettin Erbakan Üniversitesi, Meram, Konya, Turkey; [Demirkol] Yasemin Kendir, University of Health Sciences, Istanbul, Turkey; [Klocperk] Adam, Department of Immunology, Fakultní Nemocnice v Motole, Prague, Czech Republic; [Krol] Zbigniew J., Central Clinical Hospital of the Ministry of the Interior and Administration in Warsaen_US
dc.description.abstractInterindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-w (IFN-w) (13 patients), against the 13 types of IFN-a (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men. © 2020 American Association for the Advancement of Science. All rights reserved.en_US
dc.identifier.doi10.1126/science.abd4585
dc.identifier.isbn9781844654512
dc.identifier.isbn9781844652044
dc.identifier.issn0036-8075
dc.identifier.issn1095-9203
dc.identifier.issue6515en_US
dc.identifier.pmid32972996
dc.identifier.scopus2-s2.0-85094096675
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1126/science.abd4585
dc.identifier.urihttps://hdl.handle.net/20.500.12712/36381
dc.identifier.volume370en_US
dc.identifier.wosqualityQ1
dc.language.isoenen_US
dc.publisherAmerican Association for the Advancement of Scienceen_US
dc.relation.ispartofScienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleAutoantibodies Against Type I IFNs in Patients With Life-Threatening COVID-19en_US
dc.typeArticleen_US
dspace.entity.typePublication

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