Publication:
A Stereological Study of the Effects of Antidepressants on Postmenopausal Rat Kidney

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dc.authorscopusid55133866200
dc.authorscopusid15063935100
dc.authorscopusid26425788700
dc.authorscopusid24773142500
dc.authorscopusid55623179000
dc.authorscopusid6701466395
dc.contributor.authorKurtoglu Ozdes, E.
dc.contributor.authorAltunkaynak, B.Z.
dc.contributor.authorDeniz, O.G.
dc.contributor.authorİlkaya, F.
dc.contributor.authorGüzel, H.
dc.contributor.authorKökçü, A.
dc.date.accessioned2020-06-21T12:19:57Z
dc.date.available2020-06-21T12:19:57Z
dc.date.issued2020
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Kurtoglu Ozdes] Emel, Department of Obstetrics and Gynecology, Memorial Hizmet Hospital, Istanbul, Istanbul, Turkey; [Altunkaynak] Berrin Zühal, Department of Histology and Embryology, Istanbul Okan University, Tuzla, Istanbul, Turkey; [Deniz] Ömür Gülsüm, Department of Histology and Embryology, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [İlkaya] Fatih, Department of Pharmacology, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Güzel] Hasan, Department of Pharmacology, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Kökçü] Arif, Department of Obstetrics and Gynecology, Medical Park Hospital, Bursa, Turkeyen_US
dc.description.abstractMany factors can cause depression including genes (DNA), brain chemistry or stress. Antidepressant drugs affect the brain, heart, liver and kidney. We investigated the effects of the antidepressant drugs, amitriptyline (AMI) and paroxetine (PARO) on kidney. We used 24 adult female rats that were ovariectomized bilaterally 7 days before the experiment. The ovariectomized (OVX) animals and healthy control rats were divided into four equal groups for 4 weeks: control group, OVX control group (sham), AMI group and PARO group. Following the experimental period, the Cavalieri method was applied to sections of the kidney. PARO produced adverse effects on distal and proximal tubule volume, but AMI had no effect on the volume of distal and proximal tubules. Both PARO and AMI decreased the volume of Bowman spaces. PARO also damaged the kidney tubules and cells. © 2019, © 2019 The Biological Stain Commission.en_US
dc.identifier.doi10.1080/10520295.2019.1680865
dc.identifier.endpage267en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue4en_US
dc.identifier.pmid31746664
dc.identifier.scopus2-s2.0-85084326928
dc.identifier.scopusqualityQ3
dc.identifier.startpage262en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2019.1680865
dc.identifier.volume95en_US
dc.identifier.wosWOS:000498357400001
dc.identifier.wosqualityQ4
dc.language.isoenen_US
dc.publisherTaylor and Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.journalBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAmitriptylineen_US
dc.subjectAntidepressantsen_US
dc.subjectKidneyen_US
dc.subjectParoxetineen_US
dc.subjectSerotonin Re-Uptake Inhibitorsen_US
dc.subjectStereologyen_US
dc.subjectTricyclicsen_US
dc.titleA Stereological Study of the Effects of Antidepressants on Postmenopausal Rat Kidneyen_US
dc.typeArticleen_US
dspace.entity.typePublication

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