Publication:
SARS-CoV MIS-C: A Key to the Viral and Genetic Causes of Kawasaki Disease

Simple item page
dc.authorscopusid13611914400
dc.authorscopusid23026610500
dc.authorscopusid11140506200
dc.authorscopusid35101365600
dc.authorscopusid26655140600
dc.authorscopusid57204253540
dc.authorscopusid7401459381
dc.contributor.authorSancho-Shimizu, V.
dc.contributor.authorBrodin, P.
dc.contributor.authorCobat, A.
dc.contributor.authorBiggs, C.M.
dc.contributor.authorToubiana, J.
dc.contributor.authorLucas, C.L.
dc.contributor.authorHenrickson, S.E.
dc.date.accessioned2025-12-11T00:28:50Z
dc.date.issued2021
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Sancho-Shimizu] Vanessa, Department of Paediatric Infectious Diseases, Imperial College London, London, United Kingdom, Centre for Paediatrics and Child Health, Imperial College Faculty of Medicine, London, United Kingdom; [Brodin] Petter, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Stockholms, Sweden; [Cobat] Aurélie, Rockefeller Branch, Rockefeller University, New York, NY, United States, Necker Branch, Hôpital Necker Enfants Malades, Paris, France, Université Paris Cité, Paris, Ile-de-France, France; [Biggs] Catherine M., Department of Pediatrics, The University of British Columbia, Vancouver, BC, Canada, BC Children's Hospital Research Institute, Vancouver, BC, Canada; [Toubiana] Julie, Department of General Pediatrics and Pediatric Infectious Diseases, Université Paris Cité, Paris, Ile-de-France, France, Biodiversity and Epidemiology of Bacterial Pathogens, Institut Pasteur, Paris, Paris, Ile-de-France, France; [Lucas] Carrie L., Department of Immunobiology, Yale School of Medicine, New Haven, CT, United States; [Henrickson] Sarah E., Division of Allergy Immunology, The Children's Hospital of Philadelphia, Philadelphia, PA, United States, Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States; [Belot] Alexandre, Université Claude Bernard Lyon 1, Villeurbanne, Auvergne-Rhone-Alpes, France, Pediatric Nephrology, CHU de Lyon, Lyon, Auvergne-Rhone-Alpes, France; [Tangye] Stuart G., Garvan Institute of Medical Research, Sydney, NSW, Australia, UNSW Medicine, Kensington, NSW, Australia; [Milner] Joshua D., Department of Pediatrics, Columbia University, New York, NY, United States; [Levin] Michael E., Department of Paediatric Infectious Diseases, Imperial College London, London, United Kingdom, Centre for Paediatrics and Child Health, Imperial College Faculty of Medicine, London, United Kingdom; [Abel] Laurent, Rockefeller Branch, Rockefeller University, New York, NY, United States, Necker Branch, Hôpital Necker Enfants Malades, Paris, France, Université Paris Cité, Paris, Ile-de-France, France; [Bogunovic] Dusan, Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States; [Casanova] Jean Laurent, Rockefeller Branch, Rockefeller University, New York, NY, United States, Necker Branch, Hôpital Necker Enfants Malades, Paris, France, Université Paris Cité, Paris, Ile-de-France, France, Howard Hughes Medical Institute, Chevy Chase, MD, United States; [Zhang] Shenying, Rockefeller Branch, Rockefeller University, New York, NY, United States, Necker Branch, Hôpital Necker Enfants Malades, Paris, France, Université Paris Cité, Paris, Ile-de-France, France; [Haddad] Elie, Department of Pediatrics, CHU Sainte-Justine - Le Centre Hospitalier Universitaire Mère-Enfant, Montreal, QC, Canada; [Béland] Kathie, Department of Pediatrics, CHU Sainte-Justine - Le Centre Hospitalier Universitaire Mère-Enfant, Montreal, QC, Canada; [Pujol] Aurora, Neurometabolic Diseases Laboratory, Hospital Duran i Reynals, Barcelona, Barcelona, Spain, Institució Catalana de Recerca i Estudis Avançats, Barcelona, Barcelona, Spain, Instituto de Salud Carlos III, Madrid, Madrid, Spain; [Schlüter] Agatha, Neurometabolic Diseases Laboratory, Hospital Duran i Reynals, Barcelona, Barcelona, Spain; [Planas-Serra] Laura, Neurometabolic Diseases Laboratory, Hospital Duran i Reynals, Barcelona, Barcelona, Spain; [Aguilera-Albesa] Sergio, Navarra Health Service Hospital, Pamplona, Spain; [Valencia-Ramos] Juan, Complejo Asistencial Universitario de Burgos, Burgos, Burgos, Spain; [Rodríguez-Palmero Seuma] Agustí, Hospital Universitari Germans Trias i Pujol, Badalona, Spain; [Gut] Marta, Centro de Regulacion Genomica, Barcelona, Barcelona, Barcelona, Spain; [Rivière] Jacques G., Pediatric Infectious Diseases and Immunodeficiencies Unit, Universitat Autònoma de Barcelona, Cerdanyola del Valles, Barcelona, Spain; [Colobran Oriol] Roger, Immunology Division, Universitat Autònoma de Barcelona, Cerdanyola del Valles, Barcelona, Spain; [Soler-Palacín] P., Pediatric Infectious Diseases and Immunodeficiencies Unit, Universitat Autònoma de Barcelona, Cerdanyola del Valles, Barcelona, Spain; [Rodríguez-Gallego] Carlos, Department of Immunology, Hospital de Gran Canaria Dr. Negrin, Las Palmas de Gran Canaria, Las Palmas, Spain, Department of Clinical Sciences, Universidad Fernando Pessoa Canarias, Santa Maria de Guia de Gran Canaria, Las Palmas, Spain; [Pérez de Diego] Rebeca, Innate Immunity Group, Hospital Universitario La Paz, Madrid, Madrid, Spain, Interdepartmental Group of Immunodeficiencies, Madrid, Madrid, Spain; [Flores] C. M., Research Unit, Hospital Universitario Nuestra Senora de Candelaria, Santa Cruz de Tenerife, Santa Cruz de Tenerife, Spain, Genomics Division, Instituto Tecnológico y de Energías Renovables, S.A., Granadilla de Abona, Santa Cruz de Tenerife, Spain, Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Madrid, Madrid, Spain, Universidad de la Laguna, San Cristobal de La Laguna, Santa Cruz de Tenerife, Spain; [Alsina] Laia, Clinical Immunology and Primary Immunodeficiencies Unit, Hospital Sant Joan de Déu Barcelona, Esplugues de Llobregat, Barcelona, Spain; [Blázquez-Gamero] Daniel, Pediatric Infectious Diseases Unit, Instituto de Investigación Hospital 12 de Octubre, Madrid, Madrid, Spain; [Jordán] Iolanda, Pediatric Intensive Care Unit, Hospital Sant Joan de Déu Barcelona, Esplugues de Llobregat, Barcelona, Spain; [Keles] Sevgi, Necmettin Erbakan Üniversitesi, Meram, Konya, Turkey; [Emiroǧlu] Melike Keser, Department of Pediatrics, Selçuk Tip Fakültesi, Konya, Turkey; [Akcan] Ozge Metin, Necmettin Erbakan Üniversitesi, Meram, Konya, Turkey; [Alkan] Gülsüm, Selçuk Üniversitesi, Selçuklu, Konya, Turkey; [Aytekin] Selma Erol, Necmettin Erbakan Üniversitesi, Meram, Konya, Turkey; [Gul] Yahya, Necmettin Erbakan Üniversitesi, Meram, Konya, Turkey; [Tuter Oz] Sadiye Kübra, Selçuk Üniversitesi, Selçuklu, Konya, Turkey; [Bozdemir] Şefika Elmas, Bursa City Hospital, Bursa, Bursa, Turkey; [Bayhan] Gülsüm İclal, Ankara Yildirim Beyazit University, Ankara, Turkey; [Kanik-Yüksek] Saliha, Ankara City Hospital, Ankara, Ankara, Turkey; [Özkaya-Parlakay] Aslinur Inur, Ankara Yildirim Beyazit University, Ankara, Turkey; [Gülhan] Belgin, Ankara City Hospital, Ankara, Ankara, Turkey; [Yahśi] Aysun, Ankara City Hospital, Ankara, Ankara, Turkey; [Kılıç] Ahmet Osman, Necmettin Erbakan Üniversitesi, Meram, Konya, Turkey; [Karbuz] Adem, Prof. Dr. Cemil Tascioglu City Hospital, Istanbul, Istanbul, Turkey; [Erdeniz] Emine Hafize, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Ozkan] Esra Akyüz, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Orbak] Zerrin, Atatürk Üniversitesi, Erzurum, Erzurum, Turkey; [Aydemir] Şehnaz, Dr Ali Kemal Belviranli Hospital for Obstetrics and Pediatrics, Konya, Konya, Turkey; [Çelik] Jale Bengi, Selçuk Üniversitesi, Selçuklu, Konya, Turkey; [Kandemir] Bahar, Necmettin Erbakan Üniversitesi, Meram, Konya, Turkey; [Aytekin] Gökhan, Konya City Hospital, Konya, Konya, Turkey; [Kapakli] Hasan, Balıkesir Atatürk City Hospital, Balikesir, Balikesir, Turkey; [Yarar] Volkan, Balıkesir Atatürk City Hospital, Balikesir, Balikesir, Turkey; [Yosunkaya] Alper, Necmettin Erbakan Üniversitesi, Meram, Konya, Turkey; [Vatansev] Hülya, Necmettin Erbakan Üniversitesi, Meram, Konya, Turkey; [Aytekin] Caner, Department of Pediatric Immunology, Dr. Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital, Ankara, Ankara, Turkey; [Hançerli Törün] Selda, Department of Pediatric Infectious Diseases, İstanbul Tıp Fakültesi, Istanbul, Turkey; [Nepesov] Serdar, Department of Pediatric Allergy and Immunology, İstanbul Medipol Üniversitesi, Istanbul, Beykoz, Turkey; [Coşkuner] Taner, Division of Pediatric Rheumatology, University of Health Sciences, Istanbul, Turkey; [Sözeri] Betül Y., Division of Pediatric Rheumatology, University of Health Sciences, Istanbul, Turkey; [Demirkol] Yasemin Kendir, Department of Pediatric Genetics, University of Health Sciences, Istanbul, Turkey; [Kasapcopur] Ozgur, Department of Pediatric Rheumatology, İstanbul University-Cerrahpaşa Cerrahpaşa Faculty of Medicine, Istanbul, Turkey; [Yildiz] Mehmet, Department of Pediatric Rheumatology, İstanbul University-Cerrahpaşa Cerrahpaşa Faculty of Medicine, Istanbul, Turkey; [Sevketoglu] Esra, Intensive Care Unit, University of Health Sciences, Istanbul, Turkey; [Hatipoǧlu] Nevin, Pediatric Infectious Diseases Unit, University of Health Sciences, Istanbul, Turkey; [Ozcelik] Tayfun, Department of Molecular Biology and Genetics, Bilkent Üniversitesi, Ankara, Ankara, Turkey; [Yesilbas] Osman, Department of Pediatrics, Karadeniz Teknik Üniversitesi Tip Fakültesi, Trabzon, Turkey; [Gayretli-Aydın] Zeynep Gökçe, Department of Pediatrics, Karadeniz Teknik Üniversitesi Tip Fakültesi, Trabzon, Turkey; [Šedivá] Anná, Department of Immunology, Fakultní Nemocnice v Motole, Prague, Czech Republic; [Klocperk] Adam, Department of Immunology, Fakultní Nemocnice v Motole, Prague, Czech Republic; [Bloomfield] Markéta, Department of Immunology, Fakultní Nemocnice v Motole, Prague, Czech Republic, Department of Pediatrics, Charles University, Prague, Czech Republic; [Meyts] Isabelle, Department of Pediatrics, KU Leuven– University Hospital Leuven, Leuven, Vlaams-Brabant, Belgium; [Delafontaine] Selket, Department of Pediatrics, KU Leuven– University Hospital Leuven, Leuven, Vlaams-Brabant, Belgium; [Haerynck] Filomeen, Primary Immunodeficiency Research Lab, Universitair Ziekenhuis Gent, Ghent, VOV, Belgium; [Hoste] Levi, Primary Immunodeficiency Research Lab, Universitair Ziekenhuis Gent, Ghent, VOV, Belgium; [Shahrooei] Mohammad, Departement Microbiologie, Immunologie en Transplantatie, Leuven, Vlaams-Brabant, Belgium; [Marque] Laura, Department of Pediatrics, Centro Hospitalar Universitário de Santo António, Porto, Porto, Portugal; [Neves] João Farela, Primary Immunodeficiencies Unit, Hospital de Dona Estefânia, Lisbon, Portugal, Center for Chronic Diseases, CEDOC, Lisbon, Lisbon, Portugal; [Novelli] Giuseppe, Department of Biomedicine and Prevention, Università degli Studi di Roma "Tor Vergata", Rome, RM, Italy; [Novelli] Antonio, Genetica Medica, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, RM, Italy; [Aïuti] Alessandro, Pediatric Immunohematology, Università Vita-Salute San Raffaele, Milan, MI, Italy; [Casari] Giorgio, Pediatric Immunohematology, Università Vita-Salute San Raffaele, Milan, MI, Italy; [Bousfiha] Ahmed Aziz, Clinical Immunology Unit, Hassan II University of Casablanca, Casablanca, Casablanca-Settat, Morocco; [Almuhsen] Saleh Zaid, Prince Naif Center for Immunology Research, King Saud University, Riyadh, Riyad, Saudi Arabia; [Sobh] Ali, Department of Pediatrics, Mansoura University Children's Hospital, Mansoura, Dakahlia, Egypt; [Gagro] Alenka, Department of Pediatrics, Childern's Hospital Zagreb, Zagreb, Croatia, Josip Juraj Strossmayer University of Osijek Faculty of Medicine, Osijek, Osijek-Baranja, Croatia; [Bajolle] Fanny, Department of Pediatric Cardiology, Université Paris Cité, Paris, Ile-de-France, France; [Bonnet] Damien, Department of Pediatric Cardiology, Université Paris Cité, Paris, Ile-de-France, France; [Lebon] Pierre, Université Paris Cité, Paris, Ile-de-France, France; [Lei] Weite, Rockefeller Branch, Rockefeller University, New York, NY, United States; [Lee] Danyel, Rockefeller Branch, Rockefeller University, New York, NY, United States; [Seeleuthner] Yoann, Necker Branch, Inserm, Paris, Ile-de-France, France, Université Paris Cité, Paris, Ile-de-France, France; [Zhang] Peng, Rockefeller Branch, Rockefeller University, New York, NY, United States; [Maglorius] Majistor, Necker Branch, Inserm, Paris, Ile-de-France, France, Université Paris Cité, Paris, Ile-de-France, France; [Philippot] Quentin, Necker Branch, Inserm, Paris, Ile-de-France, France, Université Paris Cité, Paris, Ile-de-France, France; [Pelham] Simon J., Rockefeller Branch, Rockefeller University, New York, NY, United States; [Bastard] Paul, Necker Branch, Inserm, Paris, Ile-de-France, France, Université Paris Cité, Paris, Ile-de-France, France; [Zhang] Qian, Rockefeller Branch, Rockefeller University, New York, NY, United States; [Jouanguy] Emmanuelle, Necker Branch, Inserm, Paris, Ile-de-France, France, Université Paris Cité, Paris, Ile-de-France, France; [Puel] Anne, Necker Branch, Inserm, Paris, Ile-de-France, France, Université Paris Cité, Paris, Ile-de-France, France; [Herberg] Jethro Adam, Department of Paediatric Infectious Diseases, Imperial College London, London, United Kingdom; [Kuijpers] Taco W., Sanquin Research, Amsterdam, Netherlands, Department of Pediatric Immunology, Emma Kinderziekenhuis, Amsterdam, Noord-Holland, Netherlands; [Bellos] Evangelos, Department of Paediatric Infectious Diseases, Imperial College London, London, United Kingdom; [Kaforou] Myrsini, Department of Paediatric Infectious Diseases, Imperial College London, London, United Kingdom; [Menikou] Stephanie, Department of Paediatric Infectious Diseases, Imperial College London, London, United Kingdom; [Pan-Hammarström] Qiang, Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Stockholms, Sweden; [Hammarström] Lennart L.G., Division of Clinical Immunology, Karolinska Universitetssjukhuset, Stockholm, Stockholms, Sweden; [Abolhassani] Hassan, Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Stockholms, Sweden; [Bryceson] Yenan Troi, Center for Hematology and Regenerative Medicine, Karolinska Institutet, Stockholm, Stockholms, Sweden; [Condino‑Neto] Antonio A., Department of Immunology, Universidade de São Paulo, Sao Paulo, SP, Brazil; [Prando] Carolina, Faculdades Pequeno Príncipe, Curitiba, PR, Brazil; [Bando] Silvia Yumi, Laboratory of Pediatric Genomics, Universidade de São Paulo, Sao Paulo, SP, Brazil; [Cavalcanti] André S., Department of Pediatrics, Universidade Federal de Pernambuco, Recife, PE, Brazil; [Fellay] Jacques, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, Precision Medicine Unit, Centre Hospitalier Universitaire Vaudois, Lausanne, VD, Switzerland; [Blanchard-Hohner] Giradine, Department of Pediatrics, Hôpitaux Universitaires de Genève, Geneva, GE, Switzerland; [Mansouri] Davood, Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Disease Tehran, Tehran, Tehran, Iran; [Mahmoudi] Shima Ma, Pediatric Infectious Disease Research Center, Tehran University of Medical Sciences, Tehran, Tehran, Iran; [Boyarchuk] Oksana R., Department of Children's Diseases and Pediatric Surgery, I. Horbachevsky Ternopil National Medical University, Ternopil, Ternopil Oblast, Ukraine; [Volokha] Alla P., Department of Pediatric Infectious Diseases and Pediatric Immunology, Shupyk National Healthcare University of Ukraine, Kyiv, Ukraine; [Bondarenko] Anastasia V., Department of Pediatric Infectious Diseases and Pediatric Immunology, Shupyk National Healthcare University of Ukraine, Kyiv, Ukraine; [Stepanovskyy] Yuriy S., Department of Pediatric Infectious Diseases and Pediatric Immunology, Shupyk National Healthcare University of Ukraine, Kyiv, Ukraine; [Mogensen] Trine Hyrup, Department of Infectious Diseases, Aarhus Universitetshospital, Aarhus, Midtjylland, Denmark; [van de Beek] Diederik V.D., Amsterdam UMC - University of Amsterdam, Amsterdam, Noord-Holland, Netherlands; [Andreakos] Evangelos Th, Laboratory of Immunobiology, Academy of Athens, Athens, Attica, Greece; [Papadaki] Maria, Laboratory of Immunobiology, Academy of Athens, Athens, Attica, Greece; [Abou Tayoun] Ahmad N., Al Jalila Genomics Center, Dubai, United Arab Emirates, Department of Genetics, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates; [Halwani] Rabih, College of Medicine, University of Sharjah, Sharjah, Sharjah, United Arab Emirates; [Al-Mulla] F., Center of Genomic Medicine, Kuwait University, Kuwait City, Safat, Kuwait; [Franco-Restrepo] José Luis, Department of Microbiology and Parasitology, Universidad de Antioquia, Medellin, Antioquia, Colombia; [Lau] Yu Lung, Department of Paediatrics and Adolescent Medicine, The University of Hong Kong Li Ka Shing Faculty of Medicine, Hong Kong, Hong Kong; [Kwan] Mike Yat Wah, Princess Margaret Hospital Hong Kong, Hong Kong, China; [Imai] Kohsuke, Perinatal and Maternal Medicine, Institute of Science Tokyo, Tokyo, Japan; [Okada] Satoshi, Department of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Hiroshima, Japan; [Bolze] Alexandre, Helix, San Mateo, CA, United States; [Butte] Manish J., Department of Pediatrics, University of California, Los Angeles, Los Angeles, CA, United States; [Hsieh] Elena Wen Yuan, Department of Microbiology and Immunology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States; [Drolet] Beth Ann, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States; [Arkin] Lisa M., University of Wisconsin School of Medicine and Public Health, Madison, WI, United States; [Itan] Yuval, Icahn School of Medicine at Mount Sinai, New York, NY, United States; [Maniatis] Tom, New York Genome Center, New York, NY, United States; [Arditi] Moshe, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States; [Cooper] Megan A., Division of Rheumatology/Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO, United States; [Schmitt] Erica G., Division of Rheumatology/Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO, United States; [Chakravorty] Samya, Emory University, Atlanta, GA, United States; [Anderson] Mark S., Diabetes Center, University of California, San Francisco, San Francisco, CA, United States; [Su] Helen C., Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD, United States; [Notarangelo] Luigi Daniele, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD, United Statesen_US
dc.description.abstractMultisystem inflammatory syndrome in children (MIS-C) emerged in April 2020 in communities with high COVID-19 rates. This new condition is heterogenous but resembles Kawasaki disease (KD), a well-known but poorly understood and clinically heterogenous pediatric inflammatory condition for which weak associations have been found with a myriad of viral illnesses. Epidemiological data clearly indicate that SARS-CoV-2 is the trigger for MIS-C, which typically occurs about 1 mo after infection. These findings support the hypothesis of viral triggers for the various forms of classic KD. We further suggest that rare inborn errors of immunity (IEIs) altering the immune response to SARS-CoV-2 may underlie the pathogenesis of MIS-C in some children. The discovery of monogenic IEIs underlying MIS-C would shed light on its pathogenesis, paving the way for a new genetic approach to classic KD, revisited as a heterogeneous collection of IEIs to viruses. © 2021 Sancho-Shimizu et al.en_US
dc.identifier.doi10.1084/jem.20210446
dc.identifier.issn0022-1007
dc.identifier.issn1540-9538
dc.identifier.issue6en_US
dc.identifier.pmid33904890
dc.identifier.scopus2-s2.0-85105542114
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1084/jem.20210446
dc.identifier.urihttps://hdl.handle.net/20.500.12712/36619
dc.identifier.volume218en_US
dc.identifier.wosqualityQ1
dc.language.isoenen_US
dc.publisherRockefeller University Pressen_US
dc.relation.ispartofJournal of Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleSARS-CoV MIS-C: A Key to the Viral and Genetic Causes of Kawasaki Diseaseen_US
dc.typeArticleen_US
dspace.entity.typePublication

Files

Collections

Scopus İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu