The Application of Intrapleural Dornase Alfa Alone in a Pediatric Case

Abstract

The treatment of empyema in children is controversial. In both children and adults, in addition to empyema drainage and parenteral\rantibiotics, it has been reported that treatments of intrapleural dornase alfa alone or in combination with fibrinolytic agents have been used successfully. Although fibrinolytic treatment seems to be less invasive, it may cause traumatic or intolerable side-effects in young children. There\rare some reports in the literature about the efficacy of intrapleural dornase alfa used alone in the treatment adults with empyema. To best of our\rknowledge, there are no data related to children. In this case report, a 6-year old girl, diagnosed with empyema, resistant to intravenous antibiotics and tube drainage, treated with intrapleural dornase alfa alone, was presented. \r