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Association Among Sperm Chromatin Condensation, Sperm DNA Fragmentation and 8-OHdG in Seminal Plasma and Semen Parameters in Infertile Men With Oligoasthenoteratozoospermia

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dc.authorscopusid57289631900
dc.authorscopusid6603432100
dc.authorscopusid59157694100
dc.authorscopusid16194084100
dc.authorscopusid56353804300
dc.authorwosidOzgur Gunes, Sezgin/Afk-0596-2022
dc.authorwosidAşcı, Ramazan/A-8515-2016
dc.authorwosidGunes, Sezgin/Afk-0596-2022
dc.authorwosidGuvenc, Tolga/Aag-4599-2019
dc.authorwosidAsci, Ramazan/A-8515-2016
dc.contributor.authorHologlu, Dilara
dc.contributor.authorGunes, Sezgin
dc.contributor.authorAsci, Ramazan
dc.contributor.authorHenkel, Ralf
dc.contributor.authorGuvenc, Tolga
dc.contributor.authorIDHenkel, Ralf/0000-0003-1128-2982
dc.contributor.authorIDGuvenc, Tolga/0000-0003-1468-3415
dc.contributor.authorIDAşcı, Ramazan/0000-0002-2119-8963
dc.contributor.authorIDGunes, Sezgin/0000-0002-3103-6482
dc.contributor.authorIDHologlu, Dilara/0000-0003-0331-1720
dc.date.accessioned2025-12-11T01:36:06Z
dc.date.issued2022
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Hologlu, Dilara; Gunes, Sezgin; Asci, Ramazan] Ondokuz Mayis Univ, Hlth Sci Inst, Dept Multidisciplinary Mol Med, Samsun, Turkey; [Gunes, Sezgin] Ondokuz Mayis Univ, Fac Med, Dept Med Biol, TR-55139 Samsun, Turkey; [Asci, Ramazan] Ondokuz Mayis Univ, Fac Med, Dept Urol, Samsun, Turkey; [Henkel, Ralf] Imperial Coll London, Dept Metab Digest & Reprod, London, England; [Henkel, Ralf] Univ Western Cape, Dept Med Biosci, Bellville, South Africa; [Henkel, Ralf] Cleveland Clin, Amer Ctr Reprod Med, Cleveland, OH 44106 USA; [Guvenc, Tolga] Ondokuz May S Univ, Fac Vet Med, Dept Pathol, Samsun, Turkeyen_US
dc.descriptionHenkel, Ralf/0000-0003-1128-2982; Guvenc, Tolga/0000-0003-1468-3415; Aşcı, Ramazan/0000-0002-2119-8963; Gunes, Sezgin/0000-0002-3103-6482; Hologlu, Dilara/0000-0003-0331-1720;en_US
dc.description.abstractThe present study aimed to investigate the clinical role of standard sperm diagnosis parameters (sperm concentration, motility, morphology) as well as aniline blue staining of histones, 8-OHdG, TUNEL assay were performed on semen samples in infertile men with oligoasthenoteratozoospermia (OAT). Thirty-two infertile and ten proven fertile men were included in the study. Chromatin condensation sperm in infertile men was significantly lower compared to the fertile men (p < 0.0001). Age, sperm concentration, morphology and motility were significantly negatively correlated with chromatin condensation (p < 0.05). However, no significant correlations among the chromatin condensation, SDF and sperm DNA damage were detected in terms of 8-OHdG concentration.en_US
dc.description.sponsorshipOndokuz Mayis University Research Foundation [PYO.TIP.1904.17.012]en_US
dc.description.sponsorshipOndokuz Mayis University Research Foundation, Grant/Award Number: PYO.TIP.1904.17.012en_US
dc.description.woscitationindexScience Citation Index Expanded
dc.identifier.doi10.1111/and.14268
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue1en_US
dc.identifier.pmid34632608
dc.identifier.scopus2-s2.0-85116603522
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1111/and.14268
dc.identifier.urihttps://hdl.handle.net/20.500.12712/44786
dc.identifier.volume54en_US
dc.identifier.wosWOS:000705572400001
dc.identifier.wosqualityQ3
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAndrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject8-OHdGen_US
dc.subjectChromatin Condensationen_US
dc.subjectOATen_US
dc.subjectSemen Parametersen_US
dc.subjectSperm DNA Fragmentationen_US
dc.titleAssociation Among Sperm Chromatin Condensation, Sperm DNA Fragmentation and 8-OHdG in Seminal Plasma and Semen Parameters in Infertile Men With Oligoasthenoteratozoospermiaen_US
dc.typeArticleen_US
dspace.entity.typePublication

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