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A Validated RP-LC Method for Salmeterol and Fluticasone in Their Binary Mixtures and Their Stress Degradation Behavior Under ICH-Recommended Stress Conditions

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dc.authorscopusid55600787200
dc.authorscopusid33467797400
dc.authorscopusid6602229150
dc.authorscopusid55984370700
dc.contributor.authorAkmeşe, B.
dc.contributor.authorŞanli, S.
dc.contributor.authorŞanlı, N.
dc.contributor.authorAsan, A.
dc.date.accessioned2020-06-21T13:57:09Z
dc.date.available2020-06-21T13:57:09Z
dc.date.issued2014
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Akmeşe] Bediha, Department of Chemistry, Hitit University, Corum, Corum, Turkey, Department of Chemistry, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Şanli] Senem, Department of Chemistry, Usak University, Usak, Turkey; [Şanlı] Nurullah, Department of Chemistry, Usak University, Usak, Turkey; [Asan] Adem, Department of Chemistry, Ondokuz Mayis Üniversitesi, Samsun, Turkeyen_US
dc.description.abstractSimple, accurate, precise and fully validated analytical methods for the simultaneous determination of salmeterol xinafoate and fluticasone propionate in combined dosage forms have been developed. These drugs were exposed to thermal, photolytic, hydrolytic and oxidative stress conditions, and the stressed samples were detected by the proposed method. Additionally, pK <inf>a</inf> values of three ionizable drugs (salmeterol xinafoate, fluticasone propionate and thioridazine) were determined using by the dependence of the retention factor on pH of the mobile phase. The effect of the mobile phase composition on the ionization constant was studied by measuring the pK <inf>a</inf> in different acetonitrile-water mixtures, ranging between 50 and 65% (v/v) using LC-UV method. © 2014 Pleiades Publishing, Ltd.en_US
dc.identifier.doi10.1134/S1061934814060021
dc.identifier.endpage573en_US
dc.identifier.issn1061-9348
dc.identifier.issn1608-3199
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-84903303770
dc.identifier.scopusqualityQ3
dc.identifier.startpage563en_US
dc.identifier.urihttps://doi.org/10.1134/S1061934814060021
dc.identifier.volume69en_US
dc.identifier.wosWOS:000336400600010
dc.identifier.wosqualityQ4
dc.language.isoenen_US
dc.publisherMaik Nauka Publishing / Springer SBM compmg@maik.ruen_US
dc.relation.ispartofJournal of Analytical Chemistryen_US
dc.relation.journalJournal of Analytical Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFluticasone Propionateen_US
dc.subjectLiquid Chromatographyen_US
dc.subjectSalmeterol Xinafoateen_US
dc.titleA Validated RP-LC Method for Salmeterol and Fluticasone in Their Binary Mixtures and Their Stress Degradation Behavior Under ICH-Recommended Stress Conditionsen_US
dc.typeArticleen_US
dspace.entity.typePublication

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