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A Thiophene Derivative, 2-Bromo Has Effective Anticancer Potential with Other Biological Properties

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dc.authorscopusid57221517895
dc.authorscopusid57607459400
dc.authorscopusid57610120300
dc.authorscopusid56387553800
dc.authorscopusid57216928891
dc.authorscopusid8694518300
dc.authorscopusid57212383363
dc.contributor.authorYılmaz, C.
dc.contributor.authorOthman Pirdawid, A.
dc.contributor.authorFidan Babat, C.
dc.contributor.authorKonus, M.
dc.contributor.authorCetin, D.
dc.contributor.authorKivrak, A.
dc.contributor.authorAlgso, M.A.S.
dc.date.accessioned2025-12-11T00:29:44Z
dc.date.issued2022
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Yılmaz] Can, Department of Molecular Biology and Genetics, Van Yüzüncü Yıl Üniversitesi, Van, Turkey; [Othman Pirdawid] Ahmed, Department of Molecular Biology and Genetics, Van Yüzüncü Yıl Üniversitesi, Van, Turkey; [Fidan Babat] Ceylan, Department of Molecular Biology and Genetics, Van Yüzüncü Yıl Üniversitesi, Van, Turkey; [Konus] Metin, Faculty of Science and Arts, Hitit University, Corum, Corum, Turkey; [Cetin] Dogan, Department of Molecular Biology and Genetics, Van Yüzüncü Yıl Üniversitesi, Van, Turkey; [Kivrak] Arif, Department of Chemistry, Eskişehir Osmangazi Üniversitesi, Eskisehir, Eskisehir, Turkey; [Algso] Muheb Amjad S., Department of Chemistry, Van Yüzüncü Yıl Üniversitesi, Van, Turkey; [Arslan] Şevki, Department of Biology, Pamukkale Üniversitesi, Denizli, Denizli, Turkey; [Mutlu] Dogukan, Department of Biology, Pamukkale Üniversitesi, Denizli, Denizli, Turkey; [Otur] Çiğdem, Department of Agricultural Biotechnology, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Kurt-Kızıldoğan] Aslıhan, Department of Agricultural Biotechnology, Ondokuz Mayis Üniversitesi, Samsun, Turkeyen_US
dc.description.abstractThiophene derivatives are studied intensively due to their anticancer, antimicrobial, antioxidant and some other clinically important properties. In this study, the biological properties of a new thiophene derivative, so called BMPT, with a moderate drug score of 0.29 were tested. BMPT showed selective cytotoxicity for LnCap, HepG2 and Caco-2 cancer cell lines with EC<inf>50</inf> values of 138.573 μM, 185.931 μM, and 108.657 μM, respectively, but not on the control cell line HEK293. The increased expressions were detected for caspase3, caspase8, caspase9 and Bax; but Bcl-2 expressions were decreased at cancer cell lines. BMPT decreased the total thiol content and total GST activities at HepG2 47 % and 40 %, respectively, and, molecular docking supported inhibitory models for GSTP1-1, GSTA1-1 and GSTM2-2 were mixed, uncompetitive and uncompetitive, respectively. BMPT also showed potent antibacterial activity against Staphylococcus aureus. Related with its selective inhibition on GST activities, BMPT is proposed to have significant apoptotic effect leaded by changes, especially, in caspase 3, Bcl-2 and Bax expressions. © 2022 Wiley-VCH GmbH.en_US
dc.identifier.doi10.1002/slct.202200784
dc.identifier.issn2365-6549
dc.identifier.issue15en_US
dc.identifier.scopus2-s2.0-85128664107
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1002/slct.202200784
dc.identifier.urihttps://hdl.handle.net/20.500.12712/36773
dc.identifier.volume7en_US
dc.identifier.wosqualityQ3
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Incen_US
dc.relation.ispartofChemistryselecten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnticancer Activityen_US
dc.subjectApoptosisen_US
dc.subjectBiological Activityen_US
dc.subjectGST Inhibitionen_US
dc.subjectHeteroaromatic Compoundsen_US
dc.titleA Thiophene Derivative, 2-Bromo Has Effective Anticancer Potential with Other Biological Propertiesen_US
dc.typeArticleen_US
dspace.entity.typePublication

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