Matter and Thermal Characterisation of the Magnetic Nanoparticle-Chitosan Complex: The Microwave Hyperthermia Application on Tumour Phantom

Abstract

The application of hyperthermia by induction of magnetic nanoparticles (MNPs) presents alternative approaches for diagnosis and treatment in the clinic. Magnetic nanoparticle hyperthermia (MNPH) can selectively heat the targeted malignant cells while preserving healthy tissue. However, being able to detect the characterizations of MNPs is important to be able to identify the matter. The aim of this is the investigation of matter characterization of magnetite (Fe3O4) nanoparticles (C-MNP) coated with chitosan and the MW hyperthermia (low-intensity and electrical field values) thermal efficiency of C-MNP on healthy breast and tumour equivalent tissue. The use of low-intensity MW is an innovative treatment method that stands out due to its non-invasive nature and targeted therapy capabilities. This method can provide targeted heating. Thus, it allows for the treatment of the target area without damaging healthy tissues. This is particularly promising for clinical cancer treatments.