A New Antibacterial Silver(I) Complex Incorporating 2,5-Dimethylpyrazine and the Anti-Inflammatory Diclofenac

Abstract

AgI-containing coordination complexes have attracted attention because of their photoluminescence properties and antimicrobial activities and, in principle, these properties depend on the nature of the structural topologies. A novel two-dimensional silver(I) complex with the anti-inflammatory diclofenac molecule, namely bis{μ-2-[2-(2,6-dichloroanilino)phenyl]acetato-κ3 O,O′:O}bis(μ-2,5-dimethylpyrazine-κ2 N:N′)silver(I), [Ag2(C14H10Cl2NO2)2(C6H8N2)] n , (I), has been synthesized and characterized by single-crystal X-ray diffraction, revealing that the AgI ions are chelated by the carboxylate groups of the anionic 2-[2-(2,6-dichloroanilino)phenyl]acetate (dicl) ligand in a μ3-η1:η2 coordination mode. Each dicl ligand links three AgI atoms to generate a one-dimensional infinite chain. Adjacent chains are connected through 2,5-dimethylpyrazine (dmpyz) ligands to form a two-dimensional layer structure parallel to the crystallographic bc plane. The layers are further connected by C - H⋯π interactions to generate a three-dimensional supramolecular structure. Additionally, the most striking feature is that the structure contains an intramolecular C - H ⋯Ag anagostic interaction. Furthermore, the title complex has been tested for its in vitro antibacterial activity and is determined to be highly effective on the studied microorganisms. © 2016 International Union of Crystallography.