Lipid Peroxidation in Kidney and Testis Tissues in Experimental Hypothyroidism: The Role of Zinc

Abstract

The aim of the present study was to determine the effect of zinc supplementation and zinc deficiency on the lipid peroxidation in the testis and kidney tissues of rats with experimentally induced hypothyroidism. The experimental Groups were formed as follows: 1 - Control; 2 - Sham-Hypothyroidism; 3 - Hypothyroidism (intraperitoneal administration of 10 mg/kg/day PTU for 4 weeks); 4 - Hypothyroidism + 3 mg/kg/day zinc supplementation (4 weeks); 5 - Hypothyroidism + zinc deficiency (4 weeks). The examination of the study results revealed that hypothyroidism in testis and kidney tissues increased MDA levels and decreased GSH levels (p<0.001). Zinc supplementation in addition to hypothyroidism, however, reduced the increased MDA amount and elevated GSH levels (p<0.001). Zinc deficiency together with hypothyroidism, on the other hand, was found to produce the opposite results (p<0.001). The results of the study indicated that experimental hypothyroidism caused lipid peroxidation in kidney and testis tissues. Zinc deficiency together with hypothyroidism made lipid peroxidation more evident, while zinc supplementation significantly inhibited the increased oxidative stress by activating the antioxidant system.