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Evaluation of Bee Venom and Hyaluronic Acid in the Intra-Articular Treatment of Osteoarthritis in an Experimental Rabbit Model

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dc.authorscopusid34977175400
dc.authorscopusid14023412600
dc.authorscopusid25227980200
dc.authorscopusid15755886300
dc.authorscopusid6603750201
dc.authorscopusid51863756400
dc.authorscopusid51863756400
dc.contributor.authorNisbet, H.
dc.contributor.authorÖzak, A.
dc.contributor.authorYardimci, C.
dc.contributor.authorNisbet, C.
dc.contributor.authorYarım, M.
dc.contributor.authorKoray Bayrak, I.
dc.contributor.authorSinan Sirin, Y.
dc.date.accessioned2020-06-21T14:18:36Z
dc.date.available2020-06-21T14:18:36Z
dc.date.issued2012
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Nisbet] Hatice Özlem, Department of Surgery, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Özak] Ahmet Argun, Department of Surgery, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Yardimci] Cenk, Department of Surgery, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Nisbet] Cevat, Department of Biochemistry, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Yarım] Murat, Department of Pathology, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Koray Bayrak] I., Department of Radiology, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Sinan Sirin] Y., Department of Surgery, Ondokuz Mayis Üniversitesi, Samsun, Turkeyen_US
dc.description.abstractThe aim of this study was to investigate bee venom and hyaluronic acid in the intra-articular treatment of osteoarthritis in an experimental rabbit model. Forty-five rabbits were used and they were randomly divided into three groups (BVI, BVII, and HA) and each group was divided to two subgroups to evaluate the radiologic, magnetic resonance imaging, histopathologic, and biochemical evaluation in post treatment second week (a) and twelfth week (b). Radiologically, a significant difference was observed in the HA group (P< 0.05). The MRI evaluation of at any time in group BVI(b) was found to be different. No significant differences were seen between the groups, biochemically. Histopathologically, cellularity, and orthochromasia was evident with Safranin-O in the BVI(b) and BVII(a); adhesions were seen in the BVII(a) group and clustering of chondrocyte in the HA(b) group were found to be different. Consequently, intra-articular application of HA and BV for experimental model of osteoarthritis has no significant influence upon recovery after therapy. © 2011 Elsevier Ltd.en_US
dc.identifier.doi10.1016/j.rvsc.2011.08.007
dc.identifier.endpage493en_US
dc.identifier.issn0034-5288
dc.identifier.issn1532-2661
dc.identifier.issue1en_US
dc.identifier.pmid21963244
dc.identifier.scopus2-s2.0-84861481735
dc.identifier.scopusqualityQ1
dc.identifier.startpage488en_US
dc.identifier.urihttps://doi.org/10.1016/j.rvsc.2011.08.007
dc.identifier.volume93en_US
dc.identifier.wosWOS:000305852200088
dc.identifier.wosqualityQ2
dc.language.isoenen_US
dc.publisherElsevier Science Ltden_US
dc.relation.ispartofResearch in Veterinary Scienceen_US
dc.relation.journalResearch in Veterinary Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBee Venomen_US
dc.subjectExperimentalen_US
dc.subjectHistopathologyen_US
dc.subjectHyaluronic Aciden_US
dc.subjectMagnetic Resonanceen_US
dc.subjectOsteoarthritisen_US
dc.subjectRabbiten_US
dc.subjectRadiographyen_US
dc.titleEvaluation of Bee Venom and Hyaluronic Acid in the Intra-Articular Treatment of Osteoarthritis in an Experimental Rabbit Modelen_US
dc.typeArticleen_US
dspace.entity.typePublication

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