Publication:
Does Exogenous Nitric Oxide Influence Tympanosclerosis? An Experimental Study

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dc.authorscopusid24780641000
dc.authorscopusid25229622900
dc.authorscopusid7007135107
dc.authorscopusid35579498900
dc.authorscopusid15756792400
dc.authorscopusid16156692300
dc.contributor.authorAtmaca, S.
dc.contributor.authorErol, Y.
dc.contributor.authorÇoban, A.Y.
dc.contributor.authorYíldíz, L.
dc.contributor.authorÇengel, S.
dc.contributor.authorKoyuncu, M.
dc.date.accessioned2020-06-21T15:12:46Z
dc.date.available2020-06-21T15:12:46Z
dc.date.issued2008
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Atmaca] Sinan, Department of Otolaryngology-Head and Neck Surgery, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Erol] Yeşim, Department of Otolaryngology-Head and Neck Surgery, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Çoban] Ahmet Yilmaz, Department of Microbiology and Clinical Microbiology, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Yíldíz] Levent, Department of Pathology, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Çengel] Senem, Department of Otolaryngology-Head and Neck Surgery, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Koyuncu] Mehmet, Department of Otolaryngology-Head and Neck Surgery, Ondokuz Mayis Üniversitesi, Samsun, Turkeyen_US
dc.description.abstractObjective: We aimed to elucidate the effects of exogenous nitric oxide application via myrigotomized rat tympanic membranes on tympanosclerosis. Materials and methods: Forty male rats were included in the study. After myringotomy, nitric oxide was given to the left tympanic cavities and saline was given to the right as the control group. The procedure was repeated 3 times with weekly intervals. Three months after the first procedure, otomicroscopic examination was made and the rats were sacrificed for histologic examination. Results: Neither otomicroscopic examination, nor histologic examination of middle ears and tympanic membranes revealed any significant difference between the right and left sides. Tympanic membrane thicknesses were also similar on both sides without showing any significant difference. Conclusions: Data from this study indicate that exogenous nitric oxide application did not change the occurence of tympanosclerosis in the rat model. Other cytokine interactions are needed to start the reaction sequence leading to tympanosclerosis. © 2008 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ijporl.2008.09.008
dc.identifier.endpage1848en_US
dc.identifier.issn0165-5876
dc.identifier.issn1872-8464
dc.identifier.issue12en_US
dc.identifier.pmid18945497
dc.identifier.scopus2-s2.0-55349121465
dc.identifier.scopusqualityQ2
dc.identifier.startpage1845en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijporl.2008.09.008
dc.identifier.volume72en_US
dc.identifier.wosWOS:000261543000015
dc.identifier.wosqualityQ3
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofInternational Journal of Pediatric Otorhinolaryngologyen_US
dc.relation.journalInternational Journal of Pediatric Otorhinolaryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNitric Oxideen_US
dc.subjectTympanosclerosisen_US
dc.titleDoes Exogenous Nitric Oxide Influence Tympanosclerosis? An Experimental Studyen_US
dc.typeArticleen_US
dspace.entity.typePublication

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