Publication:
Butremycin, the 3-Hydroxyl Derivative of Ikarugamycin and a Protonated Aromatic Tautomer of 5′-Methylthioinosine From a Ghanaian Micromonospora Sp. K310

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dc.authorscopusid14052125600
dc.authorscopusid6508334939
dc.authorscopusid15064586000
dc.authorscopusid8333383800
dc.authorscopusid7801491397
dc.authorscopusid7401775490
dc.authorscopusid7401775490
dc.contributor.authorKyeremeh, K.
dc.contributor.authorAcquah, K.S.
dc.contributor.authorSazak, A.
dc.contributor.authorHoussen, W.
dc.contributor.authorTabudravu, J.
dc.contributor.authorDeng, H.
dc.contributor.authorJaspars, M.
dc.date.accessioned2020-06-21T13:58:03Z
dc.date.available2020-06-21T13:58:03Z
dc.date.issued2014
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Kyeremeh] Kwaku, Department of Chemistry, University of Ghana, Accra, Ghana; [Acquah] Kojo Sekyi, Department of Chemistry, University of Ghana, Accra, Ghana; [Sazak] Anil, Department of Biology, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Houssen] Wael E., Department of Chemistry, University of Aberdeen, Aberdeen, Scotland, United Kingdom, University of Aberdeen School of Medicine, Medical Sciences and Nutrition, Aberdeen, Scotland, United Kingdom; [Tabudravu] Jioji N., Department of Chemistry, University of Aberdeen, Aberdeen, Scotland, United Kingdom; [Deng] Hai, Department of Chemistry, University of Aberdeen, Aberdeen, Scotland, United Kingdom; [Jaspars] Marcel, Department of Chemistry, University of Aberdeen, Aberdeen, Scotland, United Kingdomen_US
dc.description.abstractA new actinomycete strain Micromonospora sp. K310 was isolated from Ghanaian mangrove river sediment. Spectroscopy-guided fractionation led to the isolation of two new compounds from the fermentation culture. One of the compounds is butremycin ( 2) which is the (3-hydroxyl) derivative of the known Streptomyces metabolite ikarugamycin (1) and the other compound is a protonated aromatic tautomer of 5′-methylthioinosine (MTI) (3). Both new compounds were characterized by 1D, 2D NMR and MS data. Butremycin (2) displayed weak antibacterial activity against Gram-positive S. aureus ATCC 25923, the Gram-negative E. coli ATCC 25922 and a panel of clinical isolates of methicillin-resistant S. aureus (MRSA) strains while 3 did not show any antibacterial activity against these microbes. © 2014 by the authors; licensee MDPI.en_US
dc.identifier.doi10.3390/md12020999
dc.identifier.endpage1012en_US
dc.identifier.issn1660-3397
dc.identifier.issue2en_US
dc.identifier.pmid24534843
dc.identifier.scopus2-s2.0-84896694446
dc.identifier.scopusqualityQ1
dc.identifier.startpage999en_US
dc.identifier.urihttps://doi.org/10.3390/md12020999
dc.identifier.volume12en_US
dc.identifier.wosWOS:000335745100018
dc.identifier.wosqualityQ1
dc.language.isoenen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofMarine Drugsen_US
dc.relation.journalMarine Drugsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMacrolactamen_US
dc.subjectMangrovesen_US
dc.subjectMicromonosporaen_US
dc.subjectTautomeren_US
dc.subjectTetramic Aciden_US
dc.titleButremycin, the 3-Hydroxyl Derivative of Ikarugamycin and a Protonated Aromatic Tautomer of 5′-Methylthioinosine From a Ghanaian Micromonospora Sp. K310en_US
dc.typeArticleen_US
dspace.entity.typePublication

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