Publication:
Synthesis and Characterization of Some New Pyrazolines and Their Inhibitory Potencies Against Carbonic Anhydrases

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dc.authorscopusid57214983122
dc.authorscopusid35738432100
dc.authorscopusid23013520200
dc.authorscopusid23027537500
dc.contributor.authorCelık, G.
dc.contributor.authorArslan, T.
dc.contributor.authorŞentürk, M.
dc.contributor.authorEkinci, D.
dc.date.accessioned2020-06-21T12:18:43Z
dc.date.available2020-06-21T12:18:43Z
dc.date.issued2020
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Celık] Gonca, Department of Chemistry, Karadeniz Technical University, Trabzon, Trabzon, Turkey; [Arslan] Tayfun, Department of Chemistry, Giresun Üniversitesi, Giresun, Giresun, Turkey; [Şentürk] Murat, Department of Basic Pharmaceutical Sciences, Aǧrı İbrahim Çeçen Üniversitesi, Agri, Agri, Turkey; [Ekinci] Deniz, Department of Agricultural Biotechnology, Ondokuz Mayis Üniversitesi, Samsun, Turkeyen_US
dc.description.abstractThe inhibition of the two human cytosolic carbonic anhydrase (hCA; EC 4.2.1.1) isozymes I and II with some new pyrazoline derivatives was investigated for the first time. The structures of the newly synthesized pyrazoline derivatives were characterized by Fourier transform-infrared spectroscopy, 1H-/13C-nuclear magnetic resonance, and mass spectrometry, and elemental analysis. Compounds 1–6 showed K<inf>i</inf> values in the range of 16.4–205.9 nM for hCA I and of 6.08–93.21 nM against hCA II. These hydroxyl and amino group-containing compounds generally were competitive inhibitors. The compounds investigated here showed effective hCA I and II inhibitory effects, in the same range as the clinically used acetazolamide, and might be used as leads for generating enzyme inhibitors, possibly targeting other CA isoforms that have not yet been assayed for their interactions with such agents. © 2020 Deutsche Pharmazeutische Gesellschaften_US
dc.identifier.doi10.1002/ardp.201900292
dc.identifier.issn0365-6233
dc.identifier.issn1521-4184
dc.identifier.issue3en_US
dc.identifier.pmid31922298
dc.identifier.scopus2-s2.0-85077861997
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1002/ardp.201900292
dc.identifier.volume353en_US
dc.identifier.wosWOS:000506571800001
dc.identifier.wosqualityQ2
dc.language.isoenen_US
dc.publisherWiley-VCH Verlag info@wiley-vch.deen_US
dc.relation.ispartofArchiv Der Pharmazieen_US
dc.relation.journalArchiv Der Pharmazieen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCarbonic Anhydraseen_US
dc.subjectChalconeen_US
dc.subjectInhibitoren_US
dc.subjectPyrazolineen_US
dc.titleSynthesis and Characterization of Some New Pyrazolines and Their Inhibitory Potencies Against Carbonic Anhydrasesen_US
dc.typeArticleen_US
dspace.entity.typePublication

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