Publication:
Effect of Levetiracetam on Penicillin Induced Epileptic Activity in Rats

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dc.authorscopusid56364108000
dc.authorscopusid6603762396
dc.authorscopusid23994048900
dc.authorscopusid6701737157
dc.contributor.authorArık, A.E.
dc.contributor.authorBaǧirici, F.
dc.contributor.authorSefil, F.
dc.contributor.authorMarangoz, C.
dc.date.accessioned2020-06-21T13:58:40Z
dc.date.available2020-06-21T13:58:40Z
dc.date.issued2014
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Arık] Aliye Erguvan, Hospital of Teaching and Research, Samsun, Samsun, Turkey; [Baǧirici] Faruk, Department of Physiology, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Sefil] Fatih, Department of Physiology, Mustafa Kemal Üniversitesi, Antakya, Turkey; [Marangoz] Cafer, Department of Physiology, Ondokuz Mayis Üniversitesi, Samsun, Turkeyen_US
dc.description.abstractThe aim of this study was to investigate the effects of levetiracetam (LEV) on penicillin-induced epileptiform activity in rats. Penicillin was applied intracerebroventricularly (icv) at a dose of 500 IU to induce epileptiform activity. LEV was given intraperitoneally (ip) at doses of 20, 40, 80 mg/kg before penicillin injection. This agent reduced epileptiform activity by decreasing spike frequencies. The mean spike frequencies decreased significantly in all the LEV treated groups. There was no significant change in the spike amplitudes of the LEV groups compared with the control group. 40 mg/kg of LEV was determined as the most effective dose on reducing epileptiform activity. The results of this study suggest that LEV is an effective antiepileptic agent in penicillin-induced epilepsy. © 2014 by Polish Neuroscience Society - PTBUN, Nencki Institute of Experimental Biology.en_US
dc.identifier.endpage275en_US
dc.identifier.issn0065-1400
dc.identifier.issn1689-0035
dc.identifier.issue3en_US
dc.identifier.pmid25231846
dc.identifier.scopus2-s2.0-84907216443
dc.identifier.scopusqualityQ3
dc.identifier.startpage266en_US
dc.identifier.volume74en_US
dc.identifier.wosWOS:000342608700004
dc.identifier.wosqualityQ4
dc.language.isoenen_US
dc.publisherNencki Institute of Experimental Biology bibl@nencki.gov.plen_US
dc.relation.ispartofActa Neurobiologiae Experimentalisen_US
dc.relation.journalActa Neurobiologiae Experimentalisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEpilepsyen_US
dc.subjectLevetiracetamen_US
dc.subjectPenicillinen_US
dc.subjectRaten_US
dc.titleEffect of Levetiracetam on Penicillin Induced Epileptic Activity in Ratsen_US
dc.typeArticleen_US
dspace.entity.typePublication

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