Propofol-Ketamine Versus Propofol-Tramadol Sedation in Children Undergoing Gastrointestinal Endoscopy

Abstract

Numerous combinations of drugs are used for sedation in upper gastrointestinal endoscopies. The aim of this study was to compare the quality of two sedation regimens in upper gastrointestinal endoscopy performed on pediatric patients. After the study approval by the local ethics committee of Ondokuz Mayıs University Hospital, written informed consent was obtained from parents. Eighty patients between the ages of 1 and 18 were randomized into two groups. Group K (n=40) received propofol 1 mg/kg + 1 mg/kg ketamine intravenously. Group T (n=40) received propofol 1 mg/kg + 1 mg/kg tramadol intravenously. In both groups, additional propofol (0.5 mg/kg) was administrated when a patient showed signs of discomfort, in order to maintain a Ramsey Sedation Scale of 4 to 5. In Group K, additional propofol requirements were significantly lower compared to Group T (p=0.003). Group K had significantly higher sedation scores than Group T at 3rd min. (p=0.028) and 20th min. (p=0.015). Recovery time increased significantly in Group K (p=0.002). Although there was no difference between two groups concerning the propofol consumption, both groups required additional propofol and tramadol resulted in a shorter recovery time compared to ketamine. © 2021 Ondokuz Mayis Universitesi. All rights reserved.