Publication:
Influence of Infliximab Pretreatment on Ischemia/Reperfusion Injury in Rat Intestine

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dc.authorscopusid56153028200
dc.authorscopusid25321125600
dc.authorscopusid52664691300
dc.authorscopusid26538713200
dc.authorscopusid6504042525
dc.authorscopusid57686622500
dc.contributor.authorAdnan Akdogan, R.
dc.contributor.authorKalkan, Y.
dc.contributor.authorTümkaya, L.
dc.contributor.authorAlaçam, H.
dc.contributor.authorErdivanlı, B.
dc.contributor.authorAydin, I.
dc.date.accessioned2020-06-21T13:59:04Z
dc.date.available2020-06-21T13:59:04Z
dc.date.issued2014
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Adnan Akdogan] Remzi, Department of Internal Medicine, Recep Tayyip Erdogan University, Rize, Turkey; [Kalkan] Yildiray, Department of Histology and Embryology, Recep Tayyip Erdogan University, Rize, Turkey; [Tümkaya] Levent, Department of Histology and Embryology, Recep Tayyip Erdogan University, Rize, Turkey; [Alaçam] Hasan, Department of Biochemistry, Ondokuz Mayis Üniversitesi, Samsun, Turkey; [Erdivanlı] Başar, Department of Anaesthesia and Intensive Care, Recep Tayyip Erdogan University, Rize, Turkey; [Aydin] Ibrahim, Department of General Surgery, Recep Tayyip Erdogan University, Rize, Turkeyen_US
dc.description.abstractThe Pringle maneuver is used in hepatic surgery to prevent blood loss but is associated with ischemia- reperfusion injury. To investigate the effect of infliximab on inflammation and apoptosis in rat intestinal mucosa during ischemia-reperfusion (IR) injury. A total of 30 male Wistar albino rats were equally divided into three groups to be subjected to (i) sham operation (sham), (ii) IR injury via Pringle maneuver (pringle) or (iii) infliximab (IFX) group (IFX was given at a dose 3 mg/kg for 3 days before IR injury). Following reperfusion period of 60 min., intestinal tissue and blood samples were taken and processed by standard histological methods. The Pringle maneuver and following reperfusion caused significant histopathological changes, increased serum transaminases' activity and the levels of oxidative stress markers and decreased glutathione peroxidase activity. IFX pretreatment partially prevented these changes. Infliximab pretreatment may protect intestinal mucosa against ischemia-reperfusion injury. Further studies are needed to investigate mechanism and evaluate safety and optimal dosing of IFX in humans exposed to the possible tissue damage by ischemia-reperfusion. © Polish Society for Histochemistry and Cytochemistry.en_US
dc.identifier.doi10.5603/FHC.2014.0004
dc.identifier.endpage41en_US
dc.identifier.issn0239-8508
dc.identifier.issn1897-5631
dc.identifier.issue1en_US
dc.identifier.pmid24802959
dc.identifier.scopus2-s2.0-84900019725
dc.identifier.scopusqualityQ3
dc.identifier.startpage36en_US
dc.identifier.urihttps://doi.org/10.5603/FHC.2014.0004
dc.identifier.volume52en_US
dc.identifier.wosWOS:000335969500004
dc.identifier.wosqualityQ4
dc.language.isoenen_US
dc.publisherVia Medica Ul. Swietokrzyska 73 Gdansk 80-180en_US
dc.relation.ispartofFOLIA HISTOCHEMICA ET CYTOBIOLOGICAen_US
dc.relation.journalFolia Histochemica Et Cytobiologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCalcineurinen_US
dc.subjectCaspase 3en_US
dc.subjectInfliximaben_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subjectOxidative Stressen_US
dc.subjectPringle Maneuveren_US
dc.subjectTNFen_US
dc.subjectTransaminasesen_US
dc.titleInfluence of Infliximab Pretreatment on Ischemia/Reperfusion Injury in Rat Intestineen_US
dc.typeArticleen_US
dspace.entity.typePublication

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