The Effects of SSRI's Plus Sildenafil Combination on Vas Deferens Contraction

Abstract

Selective serotonin reuptake inhibitors (SSRIs) induced delayed ejaculation as an adverse effect. Cause of this they have been used to treat Premature Ejaculation. Recent studies have suggested that sildenafil, a selective inhibitor of cyclic GMP specific phosphodiesterase type 5, could be beneficial in the treatment of PE. However, some studies demonstrated that sildenafil is helpfull in the treatment of SSRI induced delayed ejaculation. In the present study, we examined the effects of administration of the SSRIs plus sildenafil combination on vas deferens contractions on isolated rat vas deferens. Saline (10ml/kg) was administered to the control group rats for 15 days intraperitoneally (i.p). Fluoxetine (20 mg/kg), sertraline (10 mg/kg) or citalopram (10mg/kg) were administered to the SSRI groups for 14 days i.p and 10 ml/kg saline was administered at 15th day. SSRIs were administered to the combination groups for 14 days i.p. and 10 ml/kg sildenafil was administered at 15th day. Saline (10ml/kg) was administered to the sildenafil group for 14 days i.p and at 15th day, 10 mg/kg sildenafil was administered. Rats were exposed to the forced swimming test. After the test rats vas deferens were removed and placed in organ baths and the contraction responses induced by electrical field stimulation (EFS) were recorded. The contraction responses induced by EFS were inhibited by SSRIs. This inhibition effect was antagonized by sildenafil when administered with fluoxetine or citalopram but not with sertraline. The results thought that sildenafil could have limited the 5-HT increasing effects of fluoksetin and citalopram, having lower potency for binding to the 5-HTT in synaptic cleft, whereas could not have limited this effect of sertraline, having more potency for binding to the 5-HTT. We suggest that 5-HTT may have a role on differantiated effects of SSRIs plus sildenafil combination on vas deferens contractions. © 2009 OMÜ Tüm Haklari Saklidir.