Temporary Peritoneal Dialysis in Newborns and Children: A Single-Center Experience Over Five Years

Abstract

Aim: To evaluate the indications, complications, and outcomes of temporary peritoneal dialysis (TPD) in children with acute renal failure (ARF). Patients and methods: All patients undergoing TPD between February 2006 and January 2011 in a children's hospital were included in the study. Patient characteristics, indications, complications, and duration of TPD (DPD), requirement of re-operation, length of stay, presence of sepsis, and outcome were recorded. Results: There were 21 newborns (14 prematures), 9 infants, and 9 children. The main nephrotoxic agents were gentamicin (n 7), netilmisin (n 5), vancomycin (n 3), and ibuprophen (n 3). Patients with multiorgan failure (n 9) had significantly higher blood urea nitrogen (BUN) and creatinine levels than those without multiorgan failure (n 30) [BUN: 94 ± 27.3 vs. 34.3 ± 4.9) and creatinine: 4.1 ± 0.8 vs. 1.9 ± 0.2)]. The mean DPD was longer in mature patients than in prematures (newborn: 3.7; children: 7.1). Nine complications were observed (23) (leakage in three and poor drainage in six patients). Twenty-five patients (64.1) responded to TPD treatment and were discharged, and 14 patients (10 newborns and 7 of them were premature) died (35.9). Mortality rate was higher in prematures (n 7) and patients with a history of nephrotoxic agent (n 10). Conclusion: TPD is effective especially in neonates with ARF and it is a reliable alternative to the hemodialysis or other continuous renal replacement therapies but it is not free of complications. It has limited effects, particularly in patients with multiorgan failure. © 2012 Informa Healthcare USA, Inc.