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Immunohistochemical Distribution of Leptin in Kidney Tissues of Melatonin-Treated Diabetic Rats

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dc.authorscopusid34971025700
dc.authorscopusid22233302700
dc.authorscopusid27667663200
dc.authorscopusid36620980400
dc.authorscopusid55986343800
dc.authorscopusid36658063900
dc.authorscopusid11840174800
dc.contributor.authorEliş Yildiz, S.
dc.contributor.authorDeprem, T.
dc.contributor.authorKaradaǧ Sari, E.
dc.contributor.authorBingöl, S.A.
dc.contributor.authorKoral Taşçi, S.
dc.contributor.authorAslan, Selcuk
dc.contributor.authorNur, G.
dc.date.accessioned2020-06-21T13:46:51Z
dc.date.available2020-06-21T13:46:51Z
dc.date.issued2015
dc.departmentOndokuz Mayıs Üniversitesien_US
dc.department-temp[Eliş Yildiz] Sevda, Department of Histology and Embryology, Kafkas Üniversitesi, Kars, Turkey; [Deprem] Turgay, Department of Histology and Embryology, Kafkas Üniversitesi, Veteriner Fakültesi, Kars, Turkey; [Karadaǧ Sari] Ebru Çiğdem, Department of Histology and Embryology, Kafkas Üniversitesi, Veteriner Fakültesi, Kars, Turkey; [Bingöl] Seyit Ali, Department of Histology and Embryology, Kafkas Üniversitesi, Kars, Turkey; [Koral Taşçi] Serap, Department of Histology and Embryology, Kafkas Üniversitesi, Veteriner Fakültesi, Kars, Turkey; [Aslan] Şahin, Department of Histology and Embryology, Kafkas Üniversitesi, Veteriner Fakültesi, Kars, Turkey; [Nur] Gökhan, Hatay Food Control Laboratory, Hatay, Turkey; [Sözmen] Mahmut A., Department of Pathology, Ondokuz Mayis Üniversitesi, Samsun, Turkeyen_US
dc.description.abstractWe examined using immunohistochemistry the distribution of leptin in kidney tissues of melatonin treated, streptozotocin (STZ) diabetic rats. The animals were divided into five groups: control, sham, melatonin-treated, diabetic and melatonin-treated diabetic. Kidney sections were prepared and stained with hematoxylin and eosin, and Crossman's triple staining for histological examination. The immunohistochemical localization of leptin in the kidney tissue was determined using the streptavidin-biotin-peroxidase method. We determined that on days 7 and 14, the leptin immunoreactivity of the diabetic and melatonin-treated diabetic groups was weaker than for the other groups. Weak immunoreactivity was found in the proximal and distal tubules of the kidney in the diabetic and melatonin-treated diabetic groups on days 7 and 14, and strong immunoreactivity was found in the control, sham and melatonin groups. Melatonin application had no significant effect on leptin production in the kidney tissues of diabetic rats. © 2015 The Biological Stain Commission.en_US
dc.identifier.doi10.3109/10520295.2014.983548
dc.identifier.endpage277en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue4en_US
dc.identifier.pmid25539049
dc.identifier.scopus2-s2.0-84929090072
dc.identifier.scopusqualityQ3
dc.identifier.startpage270en_US
dc.identifier.urihttps://doi.org/10.3109/10520295.2014.983548
dc.identifier.volume90en_US
dc.identifier.wosWOS:000353524300004
dc.identifier.wosqualityQ4
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.journalBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectImmunohistochemistryen_US
dc.subjectKidneyen_US
dc.subjectLeptinen_US
dc.subjectMelatoninen_US
dc.titleImmunohistochemical Distribution of Leptin in Kidney Tissues of Melatonin-Treated Diabetic Ratsen_US
dc.typeArticleen_US
dspace.entity.typePublication

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