Extra-abdominal desmoid fibromatosis: an evaluation of clinical factors affecting local recurrence rates
Künye
Coşkun H.S., Erdoğan F., Çinka H., Dabak N. (2021) Extra-abdominal desmoid fibromatosis: an evaluation of clinical factors affecting local recurrence rates. Acta Orthopaedica et Traumatologica Turcica, 55(6), 547 - 551, Doi: 10.5152/j.aott.2021.21033Özet
Objective: The aim of this study was to determine the prognostic factors for recurrence in patients with extra-abdominal desmoidtumors (EDTs) treated surgically.Methods: This single-institution, retrospective study included patients with a histologically-proven extra-abdominal desmoidtumor between 2007 and 2018. The demographic characteristics (age, sex) of the patients, tumor characteristics (region, size,proximity to neurovascular structures, margins), treatment management (surgery and/or adjuvant radiotherapy), and clinicalresults were analyzed. The effects of these possible prognostic factors on overall and disease-free survival rates and the risk oflocal recurrence were evaluated.Results: Evaluation was made of 22 patients (16 females, 6 males) with a mean age at diagnosis of 34.7 years (range = 22-76 years).The mean follow-up was 104 months (range = 4.8-168). Tumor localization was in the upper extremity in 4 patients (18.1%), thelower extremity in 11 (50.0%), and the trunk in 7 (31.8%). The mean tumor size (maximum diameter) was 5.2 cm (range = 0.6-13cm; median = 5.8 cm), and the mean tumor volume was 181.3 ± 531.4 ml. All the 22 patients were treated surgically along withadjuvant radiotherapy (RT) administered to 8 in addition to surgery for the primary treatment of the tumor. Following primarysurgery, resection margins were R0 in 11 patients, R1 in 9 and R2 in 2. Local recurrence (LR) developed in 6 patients (27.2%)during the follow-up period. Recurrence-free survival rate (RFS) was 90.9% at one year, 74.1% at 5 years, and 61.7% at 10 years.During the follow-up, no patient died, and distant metastasis was not detected. Tumor length, resection margins, and adjuvant RTwere observed to influence the risk of local recurrence (P < 0.05).Conclusion: The results of this study have demonstrated that tumor size ≥ 5 cm and the presence of microscopic or macroscopicpositive surgical margins can increase the risk of LR, and adjuvant RT can reduce the development of LR in the management of EDT.
Kaynak
Acta Orthopaedica et Traumatologica TurcicaCilt
55Sayı
6Bağlantı
https://doi.org/10.5152/j.aott.2021.21033https://hdl.handle.net/20.500.12712/33352
https://pubmed.ncbi.nlm.nih.gov/34967745/