Evaluation of nano sized Mg@BTC metal organic framework as a drug carrier: A long term experimental and predictive theoretical study

Abstract

Metal Organic Frameworks (MOFs) have found wide applications as a drugcarrier in nanotherapeutics because of adjustable pore-sizes, controllablestructural properties, large surface area and high pore volume. In this work,nanosized Mg@BTC is synthesized by electrochemical method and used as a newdrug carrier for ibuprofen. The ibuprofen (IB) is loaded to the Mg@BTC 1:1 ratiowith the amount of %99.8. The release of ibuprofen from nanocarrier has beenobserved experimentally for long term. After 100.5 hours, the release ratio yields36 %. The ibuprofen has been tested at 40 ± 0.5 °C. System showed a rapidrelease after 100 hours, the release ratio yields 72.29 %. The release profile ofIB loaded Mg@BTC is tested by using model depended mathematical models toget observation and prediction of the release. Zero Order Model, First OrderModel, Higuchi Model, Peppas Model and Hixon Model functions are fitted to therelease profiles. Watson’s U Squared Method is used to test the fit strength of themodels. Observation from the release profiles, it is seemed Peppas Model yieldsthe best results. Also, thermodynamic analysis has been studied.