Evaluation of clinical and laboratory prognostic risk factors in organophosphate or carbamate-poisoned pediatric patients

Abstract

We aimed to determine the clinical and demographic features of pediatric patients monitored at our hospital after organophosphate or carbamate intoxication. Moreover, we aimed to determine the clinical and laboratory indicators that can affect the clinical severity scores and patients’ prognosis.Materials and Methods: We retrospectively analyzed 117 patients, aged less than 18 years and admitted to the pediatric emergency department for organophosphate or carbamate intoxication.Results: The median age was 56 months (8-226 months), and the male-to-female ratio was 1.72 (74/43). The most frequent cause of intoxication was accidental ingestion (83.8%), and the oral route was the most common (73.5%). The Glasgow Coma Scale (GCS) score and serum pseudocholinesterase level were significantly low in the following groups: patients with a severe grade of intoxication, patients admitted to the intensive care unit, and patients with complications. However, lactate and glucose levels were significantly high in the previously mentioned patient groups (p<0.001). The mean range of red cell distribution width was significantly higher in patients admitted to the intensive care unit compared with those monitored in the emergency department (p=0.029).Conclusion: This study shows that GCS score and serum pseudocholinesterase, glucose, and lactate levels at baseline can be helpful in predicting the presence of a serious intoxication and aid in the prognosis of pediatric patients.