The lipid peroxidation, glutathione and total thiol levels in experiential caustic esophagial burn

Abstract

The free radicals increases due to phagocyte cell activation, in developing acute inflamation, in rats with alkali corrosive esophagial burn. In this study, it was organized two groups as the control and caustic group. The lipid peroxidation (tbars) levels was determined in both blood and burn tissue as a sign of free radicals. In addition, the reduced glutathione and total thiol levels were determined as antioxidants. The lipid peroxidation, reduced glutathione and total thiol of both the blood and tissue were compared between two groups and there was no statistical difference (p>0.05). In conclusion, since there was no significant difference in the levels of lipid peroxidation, reduced glutathione and total thiol between control and caustic group. It can be conclude that the tissue might protect itself by using other antioxidant defence systems, against the oxidative damage.