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dc.contributor.authorYildiran, A
dc.contributor.authorErduran, E
dc.contributor.authorTekelioglu, Y
dc.contributor.authorDilber, E
dc.contributor.authorGedik, Y
dc.date.accessioned2020-06-21T15:48:51Z
dc.date.available2020-06-21T15:48:51Z
dc.date.issued2002
dc.identifier.issn0041-4301
dc.identifier.urihttps://hdl.handle.net/20.500.12712/22056
dc.descriptionWOS: 000175316000005en_US
dc.descriptionPubMed: 12026198en_US
dc.description.abstractIn this paper, we investigated the effects of short-course high-dose methylprednisolone (HDMP) treatment on the proliferation of myeloid lineage cells and on apoptosis of blast cells in eight children with acute lymphoblastic leukemia (ALL). The patients were given the HDMP treatment (30 mg/kg/d, perorally) before 9:00 a.m. for seven days. Bone marrow (BM) aspiration was done at days 0 and 3 of the HDMP treatment in all patients and at the 7(th) day of the HDMP treatment in six patients. Bone marrow blast cells had gradually decreased after the HDMP treatment by the 7(th) day. There were statistically significant differences between the mean percentages of BM blast cells at days 0 and 3, days 0 and 7, and at days 3 and 7 (p<0.05). The mean percentages of blast cell apoptosis at the 3(rd) day was significantly higher than at days 0 and 7, and apoptosis at day 0 was significantly lower than at the 7(th) day (p<0.05). The mean percentages of BM myeloid lineage cells at the 7th day was significantly higher than at days 0 and 3 (p<0.05), and the mean percentage at day 0 was significantly lower than at the 3rd day (p<0.05). These findings indicate that short-course HDMP treatment causes apoptosis on lymphoblasts and increases the proliferation of myeloid lineage cells in children with ALL.en_US
dc.language.isoengen_US
dc.publisherTurkish J Pediatricsen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectacute lymphoblastic leukemiaen_US
dc.subjectshort-course high-dose methylprednisoloneen_US
dc.subjectproliferation of myeloid lineage cellsen_US
dc.subjectapoptosis of lymphoblastic leukemic cellsen_US
dc.titleProliferation of myeloid lineage cells and apoptosis of lymphoblastic leukemic cells induced by short-course high-dose methylprednisolone in patients with acute lymphoblastic leukemiaen_US
dc.typearticleen_US
dc.contributor.departmentOMÜen_US
dc.identifier.volume44en_US
dc.identifier.issue2en_US
dc.identifier.startpage116en_US
dc.identifier.endpage121en_US
dc.relation.journalTurkish Journal of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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